Electrospun fabrication and direct coating of bio-degradable fibrous composite on orthopedic Titanium implant: Synthesis and Characterizations

Abstract

For orthopedic bone regeneration, an extracellular matrix (ECM) mimicking the composite’s ability has been highly expected by natural hard tissue along with their bio-activeness, bio-compatibleness, and bio-degradable properties. An electrospinning approach is one of the high potential processes to manufacture the porous material, and the method has highly recommended for the production of porous fibrous materials in the presence of various active compounds owing to its uniqueness of producing randomly oriented fibrous matrices with appropriate porosity. In this work, we report the fibrous composite coating process on the orthopedic titanium (Ti) plate during the process of electrospinning by simply fixing the Ti metal on the aluminum foil in the drum collector. This approach gives the bio-compatible Ti implant with ECM mimicking properties. The bio-activeness of that implant will be obtained through the presence of minerals (Sr ^2+ and Ce ^3+ ) substituted hydroxyapatite (MHAP) particles. The formation of the desired composites and their phase characteristics were carefully evaluated by Fourier Transform Infra-Red (FTIR) spectroscopy and X-ray diffraction (XRD) analysis, respectively. The formation of a fibrous network and various minerals in an appropriate manner were established by a scanning electron microscope (SEM) and energy dispersive X-ray analyzer (EDX) instruments. The important notable thing is their Vickers hardness was very lower for the Poly(3-hydroxybutyrate) (PHB) polymer containing fibrous composite. These results strongly suggest the conclusion that the synthesized fibrous composite coated material will act as a better ECM mimicking implant for orthopedic applications.

Keywords

• extracellular matrix
• electrospinning
• fibrous composite
• hydroxyapatite
• orthopedic implant