Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring (Jan 2018)
Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease
- Nelly Joseph‐Mathurin,
- Yi Su,
- Tyler M. Blazey,
- Mateusz Jasielec,
- Andrei Vlassenko,
- Karl Friedrichsen,
- Brian A. Gordon,
- Russ C. Hornbeck,
- Lisa Cash,
- Beau M. Ances,
- Thomas Veale,
- David M. Cash,
- Adam M. Brickman,
- Virginia Buckles,
- Nigel J. Cairns,
- Carlos Cruchaga,
- Alison Goate,
- Clifford R. Jack Jr.,
- Celeste Karch,
- William Klunk,
- Robert A. Koeppe,
- Daniel S. Marcus,
- Richard Mayeux,
- Eric McDade,
- James M. Noble,
- John Ringman,
- Andrew J. Saykin,
- Paul M. Thompson,
- Chengjie Xiong,
- John C. Morris,
- Randall J. Bateman,
- Tammie L.S. Benzinger,
- Dominantly Inherited Alzheimer Network
Affiliations
- Nelly Joseph‐Mathurin
- Mallinckrodt Institute of Radiology, Washington University School of MedicineSaint LouisMOUSA
- Yi Su
- Banner Alzheimer's InstitutePhoenixAZUSA
- Tyler M. Blazey
- Mallinckrodt Institute of Radiology, Washington University School of MedicineSaint LouisMOUSA
- Mateusz Jasielec
- Division of BiostatisticsWashington University School of MedicineSaint LouisMOUSA
- Andrei Vlassenko
- Mallinckrodt Institute of Radiology, Washington University School of MedicineSaint LouisMOUSA
- Karl Friedrichsen
- Mallinckrodt Institute of Radiology, Washington University School of MedicineSaint LouisMOUSA
- Brian A. Gordon
- Mallinckrodt Institute of Radiology, Washington University School of MedicineSaint LouisMOUSA
- Russ C. Hornbeck
- Mallinckrodt Institute of Radiology, Washington University School of MedicineSaint LouisMOUSA
- Lisa Cash
- Mallinckrodt Institute of Radiology, Washington University School of MedicineSaint LouisMOUSA
- Beau M. Ances
- Department of NeurologyWashington University School of MedicineSaint LouisMOUSA
- Thomas Veale
- Dementia Research CentreUCL Institute of NeurologyLondonUK
- David M. Cash
- Dementia Research CentreUCL Institute of NeurologyLondonUK
- Adam M. Brickman
- Department of NeurologyColumbia University Medical CenterNew YorkNYUSA
- Virginia Buckles
- Department of NeurologyWashington University School of MedicineSaint LouisMOUSA
- Nigel J. Cairns
- Department of NeurologyWashington University School of MedicineSaint LouisMOUSA
- Carlos Cruchaga
- Department of PsychiatryWashington University School of MedicineSaint LouisMOUSA
- Alison Goate
- Neuroscience Department LaboratoriesMount Sinai School of MedicineNew YorkNYUSA
- Clifford R. Jack Jr.
- Department of RadiologyMayo ClinicRochesterMNUSA
- Celeste Karch
- Department of NeurologyWashington University School of MedicineSaint LouisMOUSA
- William Klunk
- Departments of PsychiatryUniversity of Pittsburgh School of MedicinePittsburghPAUSA
- Robert A. Koeppe
- Department of RadiologyUniversity of MichiganAnn ArborMIUSA
- Daniel S. Marcus
- Mallinckrodt Institute of Radiology, Washington University School of MedicineSaint LouisMOUSA
- Richard Mayeux
- Department of NeurologyColumbia University Medical CenterNew YorkNYUSA
- Eric McDade
- Department of NeurologyWashington University School of MedicineSaint LouisMOUSA
- James M. Noble
- Department of NeurologyColumbia University Medical CenterNew YorkNYUSA
- John Ringman
- Memory and Aging CenterDepartment of NeurologyKeck School of Medicine at the University of Southern CaliforniaLos AngelesCAUSA
- Andrew J. Saykin
- Center for NeuroimagingDepartment of Radiology and Imaging ScienceIndiana University School of MedicineIndianapolisINUSA
- Paul M. Thompson
- Laboratory of Neuroimaging, David Geffen School of Medicine, University of CaliforniaLos AngelesCAUSA
- Chengjie Xiong
- Division of BiostatisticsWashington University School of MedicineSaint LouisMOUSA
- John C. Morris
- Department of NeurologyWashington University School of MedicineSaint LouisMOUSA
- Randall J. Bateman
- Department of NeurologyWashington University School of MedicineSaint LouisMOUSA
- Tammie L.S. Benzinger
- Mallinckrodt Institute of Radiology, Washington University School of MedicineSaint LouisMOUSA
- Dominantly Inherited Alzheimer Network
- Mallinckrodt Institute of Radiology, Washington University School of MedicineSaint LouisMOUSA
- DOI
- https://doi.org/10.1016/j.dadm.2018.08.012
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 669 – 677
Abstract
Abstract Introduction 18F‐fluorodeoxyglucose (FDG) positron emission tomography (PET) is commonly used to estimate neuronal injury in Alzheimer's disease (AD). Here, we evaluate the utility of dynamic PET measures of perfusion using 11C‐Pittsburgh compound B (PiB) to estimate neuronal injury in comparison to FDG PET. Methods FDG, early frames of PiB images, and relative PiB delivery rate constants (PiB‐R1) were obtained from 110 participants from the Dominantly Inherited Alzheimer Network. Voxelwise, regional cross‐sectional, and longitudinal analyses were done to evaluate the correlation between images and estimate the relationship of the imaging biomarkers with estimated time to disease progression based on family history. Results Metabolism and perfusion images were spatially correlated. Regional PiB‐R1 values and FDG, but not early frames of PiB images, significantly decreased in the mutation carriers with estimated year to onset and with increasing dementia severity. Discussion Hypometabolism estimated by PiB‐R1 may provide a measure of brain perfusion without increasing radiation exposure.
Keywords
