PLoS ONE (Jan 2021)

Use of volatile agents for sedation in the intensive care unit: A national survey in France.

  • Raiko Blondonnet,
  • Audrey Quinson,
  • Céline Lambert,
  • Jules Audard,
  • Thomas Godet,
  • Ruoyang Zhai,
  • Bruno Pereira,
  • Emmanuel Futier,
  • Jean-Etienne Bazin,
  • Jean-Michel Constantin,
  • Matthieu Jabaudon

DOI
https://doi.org/10.1371/journal.pone.0249889
Journal volume & issue
Vol. 16, no. 4
p. e0249889

Abstract

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BackgroundCurrent intensive care unit (ICU) sedation guidelines recommend strategies using non-benzodiazepine sedatives. This survey was undertaken to explore inhaled ICU sedation practice in France.MethodsIn this national survey, medical directors of French adult ICUs were contacted by phone or email between July and August 2019. ICU medical directors were questioned about the characteristics of their department, their knowledge on inhaled sedation, and practical aspects of inhaled sedation use in their department.ResultsAmong the 374 ICUs contacted, 187 provided responses (50%). Most ICU directors (73%) knew about the use of inhaled ICU sedation and 21% used inhaled sedation in their unit, mostly with the Anaesthetic Conserving Device (AnaConDa, Sedana Medical). Most respondents had used volatile agents for sedation for ConclusionThis survey highlights the widespread knowledge about inhaled ICU sedation in France but shows its limited use to date. Differences in education and knowledge, as well as the recent and relatively scarce literature on the use of volatile agents in the ICU, might explain the diverse practices that were observed. The low rate of mild adverse effects, as perceived by respondents, and the users' satisfaction, are promising for this potentially important tool for ICU sedation.