Chronic wireless neural population recordings with common marmosets
Jeffrey D. Walker,
Friederice Pirschel,
Marina Sundiang,
Marek Niekrasz,
Jason N. MacLean,
Nicholas G. Hatsopoulos
Affiliations
Jeffrey D. Walker
Committee on Computational Neuroscience, University of Chicago, Chicago, IL 60615, USA; Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL 60615, USA; Corresponding author
Friederice Pirschel
Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL 60615, USA
Marina Sundiang
Committee on Computational Neuroscience, University of Chicago, Chicago, IL 60615, USA
Marek Niekrasz
Department of Surgery, University of Chicago, Chicago, IL 60615, USA; The University of Chicago Neuroscience Institute, University of Chicago, Chicago, IL 60615, USA
Jason N. MacLean
Committee on Computational Neuroscience, University of Chicago, Chicago, IL 60615, USA; Department of Neurobiology, University of Chicago, Chicago, IL 60615, USA; The University of Chicago Neuroscience Institute, University of Chicago, Chicago, IL 60615, USA
Nicholas G. Hatsopoulos
Committee on Computational Neuroscience, University of Chicago, Chicago, IL 60615, USA; Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL 60615, USA; The University of Chicago Neuroscience Institute, University of Chicago, Chicago, IL 60615, USA
Summary: Marmosets are an increasingly important model system for neuroscience in part due to genetic tractability and enhanced cortical accessibility, due to a lissencephalic neocortex. However, many of the techniques generally employed to record neural activity in primates inhibit the expression of natural behaviors in marmosets precluding neurophysiological insights. To address this challenge, we have developed methods for recording neural population activity in unrestrained marmosets across multiple ethological behaviors, multiple brain states, and over multiple years. Notably, our flexible methodological design allows for replacing electrode arrays and removal of implants providing alternative experimental endpoints. We validate the method by recording sensorimotor cortical population activity in freely moving marmosets across their natural behavioral repertoire and during sleep.
