Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer’s disease

Dag Sehlin; Xiaotian T. Fang; Linda Cato; Gunnar Antoni; Lars Lannfelt; Stina Syvänen

doi:10.1038/ncomms10759

Nature Communications (Feb 2016)

Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer’s disease

Dag Sehlin,
Xiaotian T. Fang,
Linda Cato,
Gunnar Antoni,
Lars Lannfelt,
Stina Syvänen

Affiliations

Dag Sehlin: Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Rudbeck Laboratory
Xiaotian T. Fang: Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Rudbeck Laboratory
Linda Cato: Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Rudbeck Laboratory
Gunnar Antoni: Department of Medicinal Chemistry, Preclinical PET Platform, Uppsala University
Lars Lannfelt: Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Rudbeck Laboratory
Stina Syvänen: Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Rudbeck Laboratory

DOI: https://doi.org/10.1038/ncomms10759
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 11

Abstract

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Imaging tools for evaluating progression of Alzheimer’s disease have been lacking. Here the authors develop a blood brain barrier-permeable Aß probe based on a radiolabelled, anti-Aß antibody, and report age-dependent brain uptake visualized in vivo with PET in mouse models of the disease.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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