LC3-associated phagocytosis: a sorting mechanism for ubiquitinated membrane proteins?

Abstract

The process of LC3-associated phagocytosis (LAP) combines elements of phagocytosis and autophagy. LAP is involved in clearance of pathogens and cell debris, antigen presentation, and immune signaling. However, the mechanistic role of LAP is incompletely understood. Based on observations from our recent study, we propose that LAP might serve as a sorting mechanism to cluster proteins destined for degradation into discrete domains of the phagosomal membrane.

Keywords

• autophagy
• inhibitor
• lap
• lc3-associated phagocytosis
• membrane domain