DNA methylation status correlates with adult β-cell regeneration capacity

Ishant Khurana; Keith Al-Hasani; Scott Maxwell; Harikrishnan K.N.; Jun Okabe; Mark E. Cooper; Patrick Collombat; Assam El-Osta

doi:10.1038/s41536-021-00119-1

npj Regenerative Medicine (Feb 2021)

DNA methylation status correlates with adult β-cell regeneration capacity

Ishant Khurana,
Keith Al-Hasani,
Scott Maxwell,
Harikrishnan K.N.,
Jun Okabe,
Mark E. Cooper,
Patrick Collombat,
Assam El-Osta

Affiliations

Ishant Khurana: Department of Diabetes, Central Clinical School, Monash University
Keith Al-Hasani: Department of Diabetes, Central Clinical School, Monash University
Scott Maxwell: Department of Diabetes, Central Clinical School, Monash University
Harikrishnan K.N.: Department of Diabetes, Central Clinical School, Monash University
Jun Okabe: Department of Diabetes, Central Clinical School, Monash University
Mark E. Cooper: Department of Diabetes, Central Clinical School, Monash University
Patrick Collombat: Université Côte d’Azur, Inserm, CNRS, iBV
Assam El-Osta: Department of Diabetes, Central Clinical School, Monash University

DOI: https://doi.org/10.1038/s41536-021-00119-1
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 5

Abstract

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Abstract The role of DNA methylation in β-cell neogenesis is poorly understood. We report that during the process of induced cell reprogramming, methylation content of the Ngn3 and Sox11 genes are diminished. These findings emphasise DNA methylation is a barrier in β-cell regeneration in adulthood, a well described pathophysiological phenomenon of major significance in explaining β-cell deficiency in diabetes in the adult pancreas.

Published in npj Regenerative Medicine

ISSN: 2057-3995 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine
Website: https://www.nature.com/npjregenmed/

About the journal