Cinnamic acid activity against Trichlorfon pesticide toxicity and liver function enzymes in mice.

Abstract

The study was carried out to determine hepatotoxicity and hepatoprotective effects of cinnamic acid in comparison with vitamin C against the mutagenic pesticide influence of trichlorfon, which is a chemical compound that damages hepatic cells and has mutagenic effects. The effect was studied in mammalian system in mice depended on evaluating the enzymatic activity of three hepatic enzymes: Alanine Transaminase(ALT), Aspartate Transaminase (AST) and Alkaline Phosphate (ALP).Two concentrations of pure cinnamic acid (60,30) mg/body weight were tested to choose the suitable concentration which compared with negative control, positive control and comparative group of Vitamin C. In order to use in the interaction experiments, included two types of treatments pre-trichlorfon and post-trichlorfon in order to determine the mechanisms of the pure cinnamic acid, showed no toxic and hepatotoxicity influence in biological system and it showed highly performance in prevention or reduction in hepatotoxicity of trichlorfon. Cinnamic acid increased the ALT, AST and ALP enzymes with normal levels especially with dose of 30 mg/body weight. The positive effect of cinnamic acid was higher when used as post-trichlorfon treatments and to less extent in pre-trichlorfon treatments, therefore, cinnamic acid can be considered as a cure hepatocytes from acute liver damage also work protective to cardiac, skeletal muscle and placental tissue protective.

Keywords

• Cinnamic acid, Trichlorfon, Liver Function Enzymes, mice.