Journal of Lipid Research (Feb 2005)
Evidence of QTLs on chromosomes 1q42 and 8q24 for LDL-cholesterol and apoB levels in the HERITAGE Family Study
- Mary F. Feitosa,
- Ingrid B. Borecki,
- Tuomo Rankinen,
- Treva Rice,
- Jean-Pierre Després,
- Yvon C. Chagnon,
- Jacques Gagnon,
- Arthur S. Leon,
- James S. Skinner,
- Claude Bouchard,
- Michael A. Province,
- D.C. Rao
Affiliations
- Mary F. Feitosa
- Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO; Department of Genetics, Washington University School of Medicine, Saint Louis, MO; Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO; Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA; The Québec Heart Institute, Québec, Canada; Department of Genetic and Molecular Psychiatry, Laval University Research Center Robert Giffard, Beauport, Canada; Centre de Recherche sur les Biotechnologies Marines, Marine Biotechnology Research Center, Québec, Canada; School of Kinesiology, University of Minnesota, Minneapolis, MN; Department of Kinesiology, Indiana University, Bloomington, IN
- Ingrid B. Borecki
- Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO; Department of Genetics, Washington University School of Medicine, Saint Louis, MO; Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO; Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA; The Québec Heart Institute, Québec, Canada; Department of Genetic and Molecular Psychiatry, Laval University Research Center Robert Giffard, Beauport, Canada; Centre de Recherche sur les Biotechnologies Marines, Marine Biotechnology Research Center, Québec, Canada; School of Kinesiology, University of Minnesota, Minneapolis, MN; Department of Kinesiology, Indiana University, Bloomington, IN
- Tuomo Rankinen
- Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO; Department of Genetics, Washington University School of Medicine, Saint Louis, MO; Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO; Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA; The Québec Heart Institute, Québec, Canada; Department of Genetic and Molecular Psychiatry, Laval University Research Center Robert Giffard, Beauport, Canada; Centre de Recherche sur les Biotechnologies Marines, Marine Biotechnology Research Center, Québec, Canada; School of Kinesiology, University of Minnesota, Minneapolis, MN; Department of Kinesiology, Indiana University, Bloomington, IN
- Treva Rice
- Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO; Department of Genetics, Washington University School of Medicine, Saint Louis, MO; Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO; Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA; The Québec Heart Institute, Québec, Canada; Department of Genetic and Molecular Psychiatry, Laval University Research Center Robert Giffard, Beauport, Canada; Centre de Recherche sur les Biotechnologies Marines, Marine Biotechnology Research Center, Québec, Canada; School of Kinesiology, University of Minnesota, Minneapolis, MN; Department of Kinesiology, Indiana University, Bloomington, IN
- Jean-Pierre Després
- Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO; Department of Genetics, Washington University School of Medicine, Saint Louis, MO; Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO; Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA; The Québec Heart Institute, Québec, Canada; Department of Genetic and Molecular Psychiatry, Laval University Research Center Robert Giffard, Beauport, Canada; Centre de Recherche sur les Biotechnologies Marines, Marine Biotechnology Research Center, Québec, Canada; School of Kinesiology, University of Minnesota, Minneapolis, MN; Department of Kinesiology, Indiana University, Bloomington, IN
- Yvon C. Chagnon
- Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO; Department of Genetics, Washington University School of Medicine, Saint Louis, MO; Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO; Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA; The Québec Heart Institute, Québec, Canada; Department of Genetic and Molecular Psychiatry, Laval University Research Center Robert Giffard, Beauport, Canada; Centre de Recherche sur les Biotechnologies Marines, Marine Biotechnology Research Center, Québec, Canada; School of Kinesiology, University of Minnesota, Minneapolis, MN; Department of Kinesiology, Indiana University, Bloomington, IN
- Jacques Gagnon
- Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO; Department of Genetics, Washington University School of Medicine, Saint Louis, MO; Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO; Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA; The Québec Heart Institute, Québec, Canada; Department of Genetic and Molecular Psychiatry, Laval University Research Center Robert Giffard, Beauport, Canada; Centre de Recherche sur les Biotechnologies Marines, Marine Biotechnology Research Center, Québec, Canada; School of Kinesiology, University of Minnesota, Minneapolis, MN; Department of Kinesiology, Indiana University, Bloomington, IN
- Arthur S. Leon
- Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO; Department of Genetics, Washington University School of Medicine, Saint Louis, MO; Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO; Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA; The Québec Heart Institute, Québec, Canada; Department of Genetic and Molecular Psychiatry, Laval University Research Center Robert Giffard, Beauport, Canada; Centre de Recherche sur les Biotechnologies Marines, Marine Biotechnology Research Center, Québec, Canada; School of Kinesiology, University of Minnesota, Minneapolis, MN; Department of Kinesiology, Indiana University, Bloomington, IN
- James S. Skinner
- Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO; Department of Genetics, Washington University School of Medicine, Saint Louis, MO; Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO; Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA; The Québec Heart Institute, Québec, Canada; Department of Genetic and Molecular Psychiatry, Laval University Research Center Robert Giffard, Beauport, Canada; Centre de Recherche sur les Biotechnologies Marines, Marine Biotechnology Research Center, Québec, Canada; School of Kinesiology, University of Minnesota, Minneapolis, MN; Department of Kinesiology, Indiana University, Bloomington, IN
- Claude Bouchard
- Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO; Department of Genetics, Washington University School of Medicine, Saint Louis, MO; Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO; Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA; The Québec Heart Institute, Québec, Canada; Department of Genetic and Molecular Psychiatry, Laval University Research Center Robert Giffard, Beauport, Canada; Centre de Recherche sur les Biotechnologies Marines, Marine Biotechnology Research Center, Québec, Canada; School of Kinesiology, University of Minnesota, Minneapolis, MN; Department of Kinesiology, Indiana University, Bloomington, IN
- Michael A. Province
- Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO; Department of Genetics, Washington University School of Medicine, Saint Louis, MO; Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO; Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA; The Québec Heart Institute, Québec, Canada; Department of Genetic and Molecular Psychiatry, Laval University Research Center Robert Giffard, Beauport, Canada; Centre de Recherche sur les Biotechnologies Marines, Marine Biotechnology Research Center, Québec, Canada; School of Kinesiology, University of Minnesota, Minneapolis, MN; Department of Kinesiology, Indiana University, Bloomington, IN
- D.C. Rao
- Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO; Department of Genetics, Washington University School of Medicine, Saint Louis, MO; Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO; Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA; The Québec Heart Institute, Québec, Canada; Department of Genetic and Molecular Psychiatry, Laval University Research Center Robert Giffard, Beauport, Canada; Centre de Recherche sur les Biotechnologies Marines, Marine Biotechnology Research Center, Québec, Canada; School of Kinesiology, University of Minnesota, Minneapolis, MN; Department of Kinesiology, Indiana University, Bloomington, IN
- Journal volume & issue
-
Vol. 46,
no. 2
pp. 281 – 286
Abstract
Genome-wide multipoint linkage analyses were performed to identify chromosomal regions harboring genes influencing LDL-cholesterol, total apolipoprotein B (apoB), and LDL-apoB levels using 654 markers. They were assessed in a sedentary state (baseline) and after a 20 week endurance training program. Strong evidence for two quantitative trait loci (QTLs) for baseline levels was found. There is linkage evidence in black families on chromosomes 1q41-q44 [at marker D1S2860, 238 centimorgan (cM), with a maximum log of the odds (LOD) score of 3.7 for LDL-apoB] and in white families on chromosome 8q24 (at marker D8S1774, 142 cM, with LOD scores of 3.6, 3.3, and 2.5 for baseline LDL-cholesterol, LDL-apoB, and apoB, respectively). There were no strong signals for the lipoprotein training responses (as computed as the difference in posttraining minus baseline levels).In conclusion, QTLs for baseline apoB and LDL-cholesterol levels on chromosomes 1q41-q44 (in blacks) and 8q24 (in whites) were found. As there are no known strong candidate genes in these regions for lipids, follow-up studies to determine the source of those signals are needed.
