GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells

• Beibei Zhang,
• Pilar Ayuda-Durán,
• Laure Piechaczyk,
• Yngvar Fløisand,
• Mireia Mayoral Safont,
• Ida Tveit Karlsen,
• Zina Fandalyuk,
• Dagim Tadele,
• Pepijn van Mierlo,
• Alexander D. Rowe,
• Joseph M. Robertson,
• Bjørn Tore Gjertsen,
• Emmet McCormack,
• Jorrit M. Enserink

Affiliations

Beibei Zhang

Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello;Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, Montebello

Pilar Ayuda-Durán

Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello;Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, Montebello

Laure Piechaczyk

Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello;Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, Montebello;Institute of Clinical Medicine, University of Oslo

Yngvar Fløisand

Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello;Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, Montebello;Department of Hematology, Oslo University Hospital, Rikshospitalet, Oslo

Mireia Mayoral Safont

Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen

Ida Tveit Karlsen

Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen

Zina Fandalyuk

Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen

Dagim Tadele

Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello;Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, Montebello;Institute of Clinical Medicine, University of Oslo

Pepijn van Mierlo

Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello

Alexander D. Rowe

Norwegian National Unit for Newborn Screening, Woman and Children’s Division, Oslo University Hospital, Rikshospitalet

Joseph M. Robertson

Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello;Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, Montebello

Bjørn Tore Gjertsen

Department of Hematology, Oslo University Hospital, Rikshospitalet, Oslo;Hematology Section, Department of Internal Medicine, Haukeland University Hospital, Bergen

Emmet McCormack

Department of Hematology, Oslo University Hospital, Rikshospitalet, Oslo;Hematology Section, Department of Internal Medicine, Haukeland University Hospital, Bergen

Jorrit M. Enserink

Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello;Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, Montebello;Section for Biochemistry and Molecular Biology, The Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, Norway