Retinal vascular pathology in a mouse model of Lafora progressive myoclonus epilepsy

Ruchira Pranay Patil; Nitin Kumar; Arveen Kaur; Rajendra Kumar Munian; Bishakh Bhattacharya; Subramaniam Ganesh; Rashmi Parihar

Neuroscience Research (Jul 2024)

Retinal vascular pathology in a mouse model of Lafora progressive myoclonus epilepsy

Ruchira Pranay Patil,
Nitin Kumar,
Arveen Kaur,
Rajendra Kumar Munian,
Bishakh Bhattacharya,
Subramaniam Ganesh,
Rashmi Parihar

Affiliations

Ruchira Pranay Patil: Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India
Nitin Kumar: Central Experimental Animal Facility, Indian Institute of Technology, Kanpur, India
Arveen Kaur: Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India
Rajendra Kumar Munian: Department of Mechanical Engineering, Indian Institute of Technology, Kanpur, India; Department of Mechanical Engineering, Indian Institute of Technology Ropar, India
Bishakh Bhattacharya: Department of Mechanical Engineering, Indian Institute of Technology, Kanpur, India
Subramaniam Ganesh: Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India; Central Experimental Animal Facility, Indian Institute of Technology, Kanpur, India; The Mehta Family Centre for Engineering in Medicine, Indian Institute of Technology Kanpur, India; Corresponding author at: Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India.
Rashmi Parihar: Central Experimental Animal Facility, Indian Institute of Technology, Kanpur, India; Correspondence to: Central Experimental Animal Facility IndianInstitute of Technology Kanpur, Kanpur 208016, India.

Journal volume & issue: Vol. 204
pp. 58 – 63

Abstract

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Neurodegenerative diseases (ND) affect distinct populations of neurons and manifest various clinical and pathological symptoms. A subset of ND prognoses has been linked to vascular risk factors. Consequently, the current study investigated retinal vascular abnormalities in a murine model of Lafora neurodegenerative disease (LD), a fatal and genetic form of progressive myoclonus epilepsy that affects children. Here, arterial rigidity was evaluated by measuring pulse wave velocity and vasculature deformations in the retina. Our findings in the LD mouse model indicate altered pulse wave velocity, retinal vascular thinning, and convoluted retinal arteries.

Published in Neuroscience Research

ISSN: 0168-0102 (Print); 1872-8111 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.sciencedirect.com/journal/neuroscience-research

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