The factors related to the remaining positive margin after cervical conization

Abstract

Introduction: Continuation of the disease after cervical conization is probable. Knowing the risk factors involved can facilitate the selection of treatment methods and appropriate follow-up; therefore, this study was conducted with aim to determine the factors related to the remaining positive margin after cervical conization.Methods: In this retrospective cross-sectional analytical study, the clinical records of all women ≥ 18 years with intra-epithelial neoplasia (CIN) type 3 who underwent cervical conization in Imam Hossein (A) Hospital of Tehran (2017-2022) were selected by total population sampling and effective factors on the condition of the internal margin after cervical conization were investigated. The data was analyzed by SPSS software (version 23) and t and Mann-Whitney statistical tests. P<0.05 was considered statistically significant.Results: In this study, 100 people were investigated that a positive margin was found in 27 people (0.27%). Human papillovirus (HPV) infection (OR = 1.810, 95% CI = 0.071-2.74, P = 0.001), old age (OR = 0.630, 95% CI = 0.092-1.02, P = 0.002) and menopause (OR = 0.815, 95% CI = 0.096-1.32, P = 0.004), respectively with the highest chance had increased the possibility of a positive margin after cervical conization.Conclusion: Old age, menopause and HPV infection are among the risk factors of positive margin after cervical cone removal.

Keywords

• cervical conization
• cervix
• margin