PLoS ONE (Jan 2021)

Hypertriglyceridemia-associated acute pancreatitis: Response to continuous insulin infusion.

  • Vishnu Priya Pulipati,
  • Ambika Amblee,
  • Sara Elizabeth T Yap,
  • Hafeez Shaka,
  • Bettina Tahsin,
  • Leon Fogelfeld

DOI
https://doi.org/10.1371/journal.pone.0260495
Journal volume & issue
Vol. 16, no. 11
p. e0260495

Abstract

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ObjectiveTo assess the response of serum triglycerides (TG) to continuous insulin infusion (CII) in adults with hypertriglyceridemia-associated acute pancreatitis (HTGP).MethodsRetrospective analysis of TG response to standardized CII therapy in 77 adults admitted to intensive care with TG >1000 mg/dL and HTGP.ResultsParticipants had initial TG 3869.0 [2713.5, 5443.5] mg/dL and were 39.3 ± 9.7 years old, 66.2% males, 58.4% Hispanic, BMI 30.2 [27.0, 34.8] kg/m2, 74.0% with diabetes mellitus (DM) and 50.6% with excess alcohol use. TG-goal, defined as ≤1,000 ± 100 mg/dL, was achieved in 95%. Among the 73 TG-goal achievers (responders), 53.4% reached TG-goal in ConclusionCII was effective in reaching TG-goal in 95% of patients with HTGP. Half achieved TG-goal within 36 hours. Presence of DM, higher BMI and initial TG slowed the time to reach TG-goal. These baseline parameters and rate of decline to TG-50% may be real-time indicators to initiate and adjust the CII for quicker response.