Frontiers in Materials (Dec 2019)
Robust Low Friction Antibiotic Coating of Urethral Catheters Using a Catechol-Functionalized Polymeric Hydrogel Film
- Kisuk Yang,
- Kisuk Yang,
- Kisuk Yang,
- Kisuk Yang,
- Kyuri Kim,
- Eunjee A. Lee,
- Eunjee A. Lee,
- Sophie S. Liu,
- Sara Kabli,
- Sara Kabli,
- Samar A. Alsudir,
- Samar A. Alsudir,
- Shahad Albrahim,
- Angela Zhou,
- Tae Gwan Park,
- Haeshin Lee,
- Abdulaziz M. Almalik,
- Abdulaziz M. Almalik,
- Jeffrey M. Karp,
- Jeffrey M. Karp,
- Jeffrey M. Karp,
- Jeffrey M. Karp,
- Ali H. Alhasan,
- Ali H. Alhasan,
- Ali H. Alhasan,
- Yuhan Lee,
- Yuhan Lee,
- Yuhan Lee
Affiliations
- Kisuk Yang
- Engineering in Medicine, Department of Medicine, Center for Nanomedicine, Harvard Stem Cell Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States
- Kisuk Yang
- Harvard-MIT Division of Health Sciences & Technology, Cambridge, MA, United States
- Kisuk Yang
- KACST-BWH Centre of Excellence for Biomedicine, Joint Centers of Excellence Program, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia
- Kisuk Yang
- Proteomics Platform, Broad Institute of Harvard and MIT, Cambridge, MA, United States
- Kyuri Kim
- Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon, South Korea
- Eunjee A. Lee
- Engineering in Medicine, Department of Medicine, Center for Nanomedicine, Harvard Stem Cell Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States
- Eunjee A. Lee
- Harvard-MIT Division of Health Sciences & Technology, Cambridge, MA, United States
- Sophie S. Liu
- Engineering in Medicine, Department of Medicine, Center for Nanomedicine, Harvard Stem Cell Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States
- Sara Kabli
- KACST-BWH Centre of Excellence for Biomedicine, Joint Centers of Excellence Program, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia
- Sara Kabli
- National Center for Pharmaceutical Technology, Life Science and Environmental Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia
- Samar A. Alsudir
- KACST-BWH Centre of Excellence for Biomedicine, Joint Centers of Excellence Program, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia
- Samar A. Alsudir
- National Center for Pharmaceutical Technology, Life Science and Environmental Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia
- Shahad Albrahim
- KACST-BWH Centre of Excellence for Biomedicine, Joint Centers of Excellence Program, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia
- Angela Zhou
- Engineering in Medicine, Department of Medicine, Center for Nanomedicine, Harvard Stem Cell Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States
- Tae Gwan Park
- Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, South Korea
- Haeshin Lee
- Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon, South Korea
- Abdulaziz M. Almalik
- KACST-BWH Centre of Excellence for Biomedicine, Joint Centers of Excellence Program, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia
- Abdulaziz M. Almalik
- National Center for Pharmaceutical Technology, Life Science and Environmental Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia
- Jeffrey M. Karp
- Engineering in Medicine, Department of Medicine, Center for Nanomedicine, Harvard Stem Cell Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States
- Jeffrey M. Karp
- Harvard-MIT Division of Health Sciences & Technology, Cambridge, MA, United States
- Jeffrey M. Karp
- KACST-BWH Centre of Excellence for Biomedicine, Joint Centers of Excellence Program, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia
- Jeffrey M. Karp
- Proteomics Platform, Broad Institute of Harvard and MIT, Cambridge, MA, United States
- Ali H. Alhasan
- KACST-BWH Centre of Excellence for Biomedicine, Joint Centers of Excellence Program, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia
- Ali H. Alhasan
- National Center for Pharmaceutical Technology, Life Science and Environmental Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia
- Ali H. Alhasan
- College of Science and General Studies, Alfaisal University, Riyadh, Saudi Arabia
- Yuhan Lee
- Engineering in Medicine, Department of Medicine, Center for Nanomedicine, Harvard Stem Cell Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States
- Yuhan Lee
- Harvard-MIT Division of Health Sciences & Technology, Cambridge, MA, United States
- Yuhan Lee
- KACST-BWH Centre of Excellence for Biomedicine, Joint Centers of Excellence Program, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia
- DOI
- https://doi.org/10.3389/fmats.2019.00274
- Journal volume & issue
-
Vol. 6
Abstract
Indwelling urethral catheters are widely used in hospitalized patients. However, they are associated with bacterial infection and biofilm formation due to the suboptimal surface properties of the elastic materials used for the catheters. Although there are several antibacterial coating technologies to modify the surface properties of the catheter including hydrophilic polymeric coating, the risk of infection is still high given the absence of reactive functional groups on the surface of elastomers. In this study, we describe the use of catechol-functionalized hydrophilic polymers and explore strategies to create antibacterial hydrogel coatings. Three different types of catechol-functionalized polymers, chitosan, hyaluronic acid, and human serum albumin were synthesized and deposited using simple dip-coating method. All of the tested polymers could coat different types of elastomers widely used for urethral catheters independent of the surface properties while the thickness of the coating could be controlled by the number of depositions. The coating formed stable water-containing lubricant surface beneficial as a physical repellant of microbial attachment. In addition, the coating could be combined with additional antibacterial agents such as silver nanoparticles to maximize the antibacterial effect on the surface of urethral catheter materials.
Keywords
