MICROCIRCULATORY AND TISSUE THEORY: INTEGRAL VISION OF CARCINOGENESIS

Abstract

The brief review presents the main provisions of the molecular-genetic theory of carcinogenesis. The data on the presence of overcelled mechanisms regulating of tissue homeostasis has done, which can be explained by molecular genetic approach. The data of the interpretation of the theory of the oncogene based on different pathogenetic concepts is considered and it allows you to continue the development of tissue theory of carcinogenesis. The current understanding of the structural and functional characteristics of the microvasculature is described. Compelling author’s data on the effect of oxygen therapy is provided (normobaric and hyperbaric oxygen therapy), and the modulation of antioxidant activity of plasma by controlled differentiation of malignant cells with surgery (the change in the retrograde antegrade flow through the vascular reverse ).The significance of microcirculation of tissue homeostasis has determined. The updated position of the ground tissue microcirculatory theory of carcinogenesis has formulated.

Keywords

• микроциркуляция
• оксигенотерапия
• сосудистый реверс
• молекулярно-генетическая теория
• канцерогенез
• тканевая теория
• перекисное окисление
• липиды
• антиокислительная активность
• опухоль
• микроциркуляторно-тканевая теория