Journal of the Serbian Chemical Society (Jan 2015)

Synthesis, structural characterization and antimicrobial evaluation of some novel piperidin-4-one oxime esters

  • Krishnan Gokula K.,
  • Sivakumar R.,
  • Thanikachalam V.

Journal volume & issue
Vol. 80, no. 9
pp. 1101 – 1111


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Fifteen novel biologically active piperidin-4-one oxime esters (8-22) have been synthesized with good yields. These compounds were prepared from in-situ activated carboxylic acids using POCl3 and pyridine with piperidin-4- one oximes. The structure of the title compounds were elucidated on the basis of FT-IR, NMR (1D and 2D) and mass spectral analyses. The single crystal XRD study of compounds 12 and 20 were the further evidence for the proposed structure unambiguously. All the synthesized compounds were tested for in vitro antibacterial and antifungal activities. Many of these derivatives exhibited good activity against Bacillus subtilis, Pseudomonas aeruginosa, Escherichia coli, Trigoderma veride and Aspergillus flavus.