COMPARING MOLECULAR EFFECTS OF VARIOUS CYTOPROTECTORS IN COMPLEX THERAPY OF CORONARY HEART DISEASE

Abstract

The molecular effects of trimetazidine and mildronate were investigated in patients with stable effort angina, Functional Class (FC) I-III. The comparison criteria included blood activity and concentrations of the main products of free-radical oxidation and the components of Krebs cycle and anti-oxidant system. Proteomic methods were also used. Trimetazidine and mildronate could be recommended as cardio-protectors in primary and secondary prevention of FC I-III coronary heart disease.

Keywords

• coronary heart disease
• free-radical oxidation
• cytochemistry
• proteomics
• trimetazidine
• mildronate