Modification patterns and metabolic characteristics of m6A regulators in digestive tract tumors
Bing He,
Yiyang Hu,
Hui Chen,
Xia Xie,
Chunli Gong,
Zhibin Li,
Yang Chen,
Yufeng Xiao,
Shiming Yang
Affiliations
Bing He
Department of Gastroenterology, Xinqiao Hospital, Army Military Medical University, Chongqing, 400037, China
Yiyang Hu
Department of Gastroenterology, Xinqiao Hospital, Army Military Medical University, Chongqing, 400037, China
Hui Chen
Department of Gastroenterology, Xinqiao Hospital, Army Military Medical University, Chongqing, 400037, China
Xia Xie
Department of Gastroenterology, Xinqiao Hospital, Army Military Medical University, Chongqing, 400037, China
Chunli Gong
Department of Gastroenterology, Xinqiao Hospital, Army Military Medical University, Chongqing, 400037, China
Zhibin Li
Department of Gastroenterology, Xinqiao Hospital, Army Military Medical University, Chongqing, 400037, China
Yang Chen
Department of Gastroenterology, Xinqiao Hospital, Army Military Medical University, Chongqing, 400037, China
Yufeng Xiao
Corresponding authors. Department of Gastroenterology, Xinqiao Hospital, Army Military Medical University, No.183, Xinqiao Main ST, Shapingba District, 12 Chongqing 400037, China.; Department of Gastroenterology, Xinqiao Hospital, Army Military Medical University, Chongqing, 400037, China
Shiming Yang
Corresponding authors. Department of Gastroenterology, Xinqiao Hospital, Army Military Medical University, No.183, Xinqiao Main ST, Shapingba District, 12 Chongqing 400037, China.; Department of Gastroenterology, Xinqiao Hospital, Army Military Medical University, Chongqing, 400037, China
M6A is essential for tumor occurrence and progression. The expression patterns of m6A regulators differ in various kinds of tumors. Transcriptomic expression statistics together with clinical data from a database were analyzed to distinguish patients with digestive tract tumors. Based on the expression patterns of diverse m6A regulators, patients were divided into several clusters. Survival analysis suggested significant differences in patient prognosis among the m6A clusters. The results showed overlapping of m6A expression patterns with energy metabolism and nucleotide metabolism. Functional analyses imply that m6A modifications in tumor cells probably drive metabolic reprogramming to sustain rapid proliferation of cancer cells. Our analysis highlights the m6A risk characterizes various kinds of metabolic features and predicts chemotherapy sensitivity in digestive tract tumors, providing evidence for m6A regulators as markers to predict patient outcomes.
