Epigenetic regulation of Neuregulin 1 promotes breast cancer progression associated to hyperglycemia

Changhu Lee; Min Kim; Chanho Park; Woobeen Jo; Jeong Kon Seo; Sahee Kim; Jiyoung Oh; Chu-Sook Kim; Han Suk Ryu; Kyung-Hun Lee; Jiyoung Park

doi:10.1038/s41467-023-36179-8

Nature Communications (Jan 2023)

Epigenetic regulation of Neuregulin 1 promotes breast cancer progression associated to hyperglycemia

Changhu Lee,
Min Kim,
Chanho Park,
Woobeen Jo,
Jeong Kon Seo,
Sahee Kim,
Jiyoung Oh,
Chu-Sook Kim,
Han Suk Ryu,
Kyung-Hun Lee,
Jiyoung Park

Affiliations

Changhu Lee: Department of Biological Sciences, College of Information and Biotechnology, Ulsan National Institute of Science and Technology
Min Kim: Department of Biological Sciences, College of Information and Biotechnology, Ulsan National Institute of Science and Technology
Chanho Park: Department of Biological Sciences, College of Information and Biotechnology, Ulsan National Institute of Science and Technology
Woobeen Jo: Department of Biological Sciences, College of Information and Biotechnology, Ulsan National Institute of Science and Technology
Jeong Kon Seo: UNIST Central Research Facility, Ulsan National Institute of Science and Technology
Sahee Kim: Department of Biological Sciences, College of Information and Biotechnology, Ulsan National Institute of Science and Technology
Jiyoung Oh: Department of Biological Sciences, College of Information and Biotechnology, Ulsan National Institute of Science and Technology
Chu-Sook Kim: Department of Biological Sciences, College of Information and Biotechnology, Ulsan National Institute of Science and Technology
Han Suk Ryu: Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine
Kyung-Hun Lee: Department of Internal Medicine, Seoul National University Hospital, Cancer Research Institute, Seoul National University
Jiyoung Park: Department of Biological Sciences, College of Information and Biotechnology, Ulsan National Institute of Science and Technology

DOI: https://doi.org/10.1038/s41467-023-36179-8
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 15

Abstract

Read online

Despite hyperglycemia has been associated to breast cancer, the underlying mechanisms are not completely understood. Here, the authors show that epigenetic regulation of Nrg1 gene during hyperglycemia promotes breast cancer development.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal