Five undescribed plant-derived bisphenols from Artemisia capillaris aerial parts: Structure elucidation, anti-hepatoma activities and plausible biogenetic pathway

Lanlan Ge; Qiujie Xie; Xiaofang Wei; Yangfang Li; Wanying Shen; Yunguang Hu; Jie Yao; Shuling Wang; Xiao Du; Xiaobin Zeng

Arabian Journal of Chemistry (Apr 2023)

Five undescribed plant-derived bisphenols from Artemisia capillaris aerial parts: Structure elucidation, anti-hepatoma activities and plausible biogenetic pathway

Lanlan Ge,
Qiujie Xie,
Xiaofang Wei,
Yangfang Li,
Wanying Shen,
Yunguang Hu,
Jie Yao,
Shuling Wang,
Xiao Du,
Xiaobin Zeng

Affiliations

Lanlan Ge: Center Lab of Longhua Branch and Department of Infectious Disease, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, So uthern University of Science and Technology), Shenzhen 518020, Guangdong Province, PR China; Department of pathology (Longhua Branch), Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518120, Guangdong Province, PR China
Qiujie Xie: Center Lab of Longhua Branch and Department of Infectious Disease, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, So uthern University of Science and Technology), Shenzhen 518020, Guangdong Province, PR China
Xiaofang Wei: Center Lab of Longhua Branch and Department of Infectious Disease, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, So uthern University of Science and Technology), Shenzhen 518020, Guangdong Province, PR China; College of pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, PR China
Yangfang Li: Center Lab of Longhua Branch and Department of Infectious Disease, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, So uthern University of Science and Technology), Shenzhen 518020, Guangdong Province, PR China
Wanying Shen: Center Lab of Longhua Branch and Department of Infectious Disease, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, So uthern University of Science and Technology), Shenzhen 518020, Guangdong Province, PR China; College of pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, PR China
Yunguang Hu: Guangdong Yifang Pharmaceutical Co., Ltd., Foshan 528241, Guangdong Province, PR China
Jie Yao: Center Lab of Longhua Branch and Department of Infectious Disease, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, So uthern University of Science and Technology), Shenzhen 518020, Guangdong Province, PR China
Shuling Wang: College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou 311121, Zhejiang Province, PR China
Xiao Du: College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou 311121, Zhejiang Province, PR China; China Resources Sanjiu Medical & Pharmaceutical Co., Ltd., Shenzhen 518110, Guangdong Province, PR China; Corresponding authors at: College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou 311121, Zhejiang Province, PR China (Xiao Du) and Center Lab of Longhua Branch and Department of Infectious Disease, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, So uthern University of Science and Technology), Shenzhen 518020, Guangdong Province, PR China (Xiaobin Zeng).
Xiaobin Zeng: Center Lab of Longhua Branch and Department of Infectious Disease, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, So uthern University of Science and Technology), Shenzhen 518020, Guangdong Province, PR China; Department of pathology (Longhua Branch), Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518120, Guangdong Province, PR China; Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Medicine School of Shenzhen University, Shenzhen 518037, Guangdong Province, PR China; Corresponding authors at: College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou 311121, Zhejiang Province, PR China (Xiao Du) and Center Lab of Longhua Branch and Department of Infectious Disease, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, So uthern University of Science and Technology), Shenzhen 518020, Guangdong Province, PR China (Xiaobin Zeng).

Journal volume & issue: Vol. 16, no. 4
p. 104580

Abstract

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Yin-Chen, which belongs to the Asteraceae family and the genus Artemisia, is among the most abundantly used traditional medicines in China for the treatment of hepatitis and bilious disorder. Herein, five undescribed plant-derived bisphenols, capillarisenols A–E (13, 15, 25, 29, 31), and one undescribed phenolic compound (32), together with 32 known phenolic compounds (1–12, 14, 16–24, 26–28, 30, 33–38), were isolated and identified based on spectroscopic evidence from aerial parts of Artemisia capillaris Thunb. Capillarisenols A–E are the type of bisphenols firstly isolated from this plant. The plausible biogenetic pathway of new compounds was also proposed. In addition, the potential anti-hepatoma effects on Huh7 and HepG2 cell lines of all isolated compounds were evaluated in vitro. Capillarisenol C (25) showed significant anti-hepatoma activity in Huh7 and HepG 2 cells, with IC50 values of 4.96 and 8.58 μM, better than the positive control drug (Lenvatinib). This study provided phytochemical evidence for further development and utilisation of A. capillaris in health products.

Published in Arabian Journal of Chemistry

ISSN: 1878-5352 (Print)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Chemistry
Website: http://www.journals.elsevier.com/arabian-journal-of-chemistry/

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