Nature Communications (Oct 2021)
mTOR-related synaptic pathology causes autism spectrum disorder-associated functional hyperconnectivity
- Marco Pagani,
- Noemi Barsotti,
- Alice Bertero,
- Stavros Trakoshis,
- Laura Ulysse,
- Andrea Locarno,
- Ieva Miseviciute,
- Alessia De Felice,
- Carola Canella,
- Kaustubh Supekar,
- Alberto Galbusera,
- Vinod Menon,
- Raffaella Tonini,
- Gustavo Deco,
- Michael V. Lombardo,
- Massimo Pasqualetti,
- Alessandro Gozzi
Affiliations
- Marco Pagani
- Functional Neuroimaging Laboratory, Istituto Italiano di Tecnologia, Center for Neuroscience and Cognitive Systems @ University of Trento
- Noemi Barsotti
- Department of Biology, Unit of Cell and Developmental Biology, University of Pisa
- Alice Bertero
- Functional Neuroimaging Laboratory, Istituto Italiano di Tecnologia, Center for Neuroscience and Cognitive Systems @ University of Trento
- Stavros Trakoshis
- Department of Psychology, University of Cyprus
- Laura Ulysse
- Center for Brain and Cognition, Computational Neuroscience Group, Department of Information and Communication Technologies
- Andrea Locarno
- Neuromodulation of Cortical and Subcortical Circuits Laboratory, Istituto Italiano di Tecnologia
- Ieva Miseviciute
- Neuromodulation of Cortical and Subcortical Circuits Laboratory, Istituto Italiano di Tecnologia
- Alessia De Felice
- Functional Neuroimaging Laboratory, Istituto Italiano di Tecnologia, Center for Neuroscience and Cognitive Systems @ University of Trento
- Carola Canella
- Functional Neuroimaging Laboratory, Istituto Italiano di Tecnologia, Center for Neuroscience and Cognitive Systems @ University of Trento
- Kaustubh Supekar
- Stanford University
- Alberto Galbusera
- Functional Neuroimaging Laboratory, Istituto Italiano di Tecnologia, Center for Neuroscience and Cognitive Systems @ University of Trento
- Vinod Menon
- Stanford University
- Raffaella Tonini
- Neuromodulation of Cortical and Subcortical Circuits Laboratory, Istituto Italiano di Tecnologia
- Gustavo Deco
- Center for Brain and Cognition, Computational Neuroscience Group, Department of Information and Communication Technologies
- Michael V. Lombardo
- Laboratory for Autism and Neurodevelopmental Disorders, Istituto Italiano di Tecnologia, Center for Neuroscience and Cognitive Systems @ University of Trento
- Massimo Pasqualetti
- Functional Neuroimaging Laboratory, Istituto Italiano di Tecnologia, Center for Neuroscience and Cognitive Systems @ University of Trento
- Alessandro Gozzi
- Functional Neuroimaging Laboratory, Istituto Italiano di Tecnologia, Center for Neuroscience and Cognitive Systems @ University of Trento
- DOI
- https://doi.org/10.1038/s41467-021-26131-z
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Autism spectrum disorder (ASD) is characterised by synaptic surplus and atypical functional connectivity. Here, the authors show that synaptic pathology in Tsc2 haploinsufficient mice is associated with autism-like behavior and cortico-striatal hyperconnectivity, and that analogous functional hyperconnectivity signatures can be linked to mTOR-pathway dysfunction in subgroups of children with idiopathic ASD.
