HPV self-sampling for cervical cancer screening in China: A multi-center study
Xuechao Ji,
Menglin Hao,
Yixiao Wang,
Zangyu Pan,
Ruiye Yang,
Xinbo Wang,
Hui Wang,
Chunlian Zhang,
Yiqun Zhang,
Xumei Zhang,
Yongxiang Zhang,
Ge Yang,
Sarendalai,
Tunala,
Jinwei Miao
Affiliations
Xuechao Ji
Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, China
Menglin Hao
Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, China
Yixiao Wang
Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, China
Zangyu Pan
Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, China
Ruiye Yang
Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, China
Xinbo Wang
Department of Gynecology, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, China
Hui Wang
Department of Gynecology, Affiliated Hospital of Shandong Second Medical University, China
Chunlian Zhang
Department of Obstetrics and Gynecology, Taihe Hospital, Hubei University of Medicine, China
Yiqun Zhang
Department of Obstetrics and Gynecology, Taihe Hospital, Hubei University of Medicine, China
Xumei Zhang
Department of Gynecology, Yan'an Hospital Affiliated to Kunming Medical University, China
Yongxiang Zhang
Department of Gynecology, Qinghai Provincial Traffic Hospital, China
Ge Yang
Department of Obstetrics and Gynecology, Lhasa People's Hospital, China
Sarendalai
Department of Obstetrics and Gynecology, Ordos Dekang Hospital, China
Tunala
Department of Obstetrics and Gynecology, Ordos Dekang Hospital, China
Jinwei Miao
Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, China; Corresponding author. Department of Gynecologic Oncology, Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital. Qi-he-lou street No.17, Dongcheng District, Beijing, 100006, China.
Background: Human papillomavirus (HPV) self-sampling is a new method for collecting cervical isolated cells, but research been carried out in multi-ethnic and multi-regional areas of China is scarce. Objectives: We aimed to evaluate the accuracy and acceptability of HPV self-sampling and analyze the characteristics of HPV infection. Study design: Women aged 25–65 years were recruited from 8 provinces in China. Women underwent clinician-sampling and self-sampling and were asked to complete a 65-question questionnaire on their acceptance of HPV self-sampling. The paired samples were analyzed for 23 genotypes of HPV by polymerase chain reaction. Results: 5551 women were recruited, of which 5417 were eligible for analysis. 3163 women have completed and submitted the questionnaire. The top five infection genotypes were HPV 52, 58, 16, 39, and 68. The highest infection rate was in the 25–30 years group. The crude agreement between self-sampling and clinician-sampling was 93.06 %. 43.79 % of women preferred self-sampling over clinician-sampling, and 67.59 % preferred doing self-sampling at the hospital. Conclusion: HPV self-sampling could be an effective supplement to traditional cervical screening in China. Clinicians’ advocacy, timely reminders and guidance for women with abnormal self-sampling results are needed. In addition, new vaccination and cervical screening recommendations might be adjusted to fit populations with different characteristics.
