Research progress of anti-inflammatory agents in the treatment of major depressive disorder

Abstract

Major depressive disorder is one of the common mental disorders， and its pathogenesis is not yet fully understood. Elevated levels of inflammation are recognized as one of the mechanisms contributing to the onset of major depressive disorder. Numerous studies have indicated that non-steroidal anti-inflammatory drugs， omega-3 fatty acids， statins， pioglitazone， minocycline， N-acetylcysteine， corticosteroids and other medications may exert anti-depressant effects through their anti-inflammatory actions. This article provides a comprehensive review of the application of these drugs in the treatment of major depressive disorder， exploring the therapeutic effects and potential mechanisms of action of different anti-inflammatory agents， thereby offering a reference for the future application of anti-inflammatory interventions in the treatment of depression. ［Funded by The Ministry of Science and Technology of the People's Republic of China （Number， 2022ZD0211700）］

Keywords

• major depressive disorder
• anti-inflammatory effects
• efficacy
• inflammatory mechanism