Glu 298-Asp And T786-C Polymorphisms Of Endothelial Nitric Oxide Synthase Gene In Coronary Artery Disease Patients

Abstract

Aim: We aimed to investigate the association of eNOS gene with Glu298-Asp and T-786C polymorphisms with Coronary artery disease (CAD) and to contribute to the elucidation of the genetic factors involved in the development of CAD. Patients and Methods: A total of 200 patients were evaluated. Severe CAD was defined as ≥ 50% stenosis in at least one of major coronary arteries and these patients were taken into the CAD group (n=144). Patients without stenosis were included in the control group (n=66). Results: After the evaluation of T-786C polymorphism, there was no significant dif-ference between TT (p=0,660), TC (p=0,73) and CC (p=0,634) genotypes between CAD and control groups. There was no significant difference between the groups in both dominant (p=0,439) and recessive (p=0,622) model comparisons. When Glu 298-Asp polymorphism was examined, there was no statistically significant difference between GG (p=0,836), GT (p=0,581) and TT (p=0,767) genotypes when the groups were compared according to genotype distributions. The groups were statistically similar according to both dominant (p=0,697) and recessive (p=0,485) model com-parisons. Conclusion: There was no statistical correlation between T-786 C and Glu 298-Asp polymorphisms and CAD. Similar studies with larger study populations should be conducted to clarify the role of T-786 C and Glu 298-Asp polymorphisms.

Keywords

• endothelial nitric oxide synthase
• coronary artery disease
• nitric oxide
• t-786c polymorphism
• glu298-asp polymorphism
• endotelyal nitrik oksit sentaz
• koroner arter hastalığı
• nitrik oksit
• t-786c polimorfizmi
• glu298-asp polimorfizmi