International Journal of Infectious Diseases (Jul 2021)
SARS-CoV-2 reinfection with a virus harboring mutation in the Spike and the Nucleocapsid proteins in Panama
- Yamilka Díaz,
- Anyuri Ortiz,
- Adriana Weeden,
- Daniel Castillo,
- Claudia González,
- Brechla Moreno,
- Mabel Martínez-Montero,
- Marlene Castillo,
- Grettel Vasquez,
- Lisseth Sáenz,
- Danilo Franco,
- Yaneth Pitti,
- Oris Chavarria,
- Jessica Gondola,
- Ambar M. Moreno,
- Leyda Ábrego,
- Davis Beltrán,
- Ilka Guerra,
- Jim Chang,
- Zumara Chaverra,
- Isela Guerrero,
- Alejandra Valoy,
- Melissa Gaitán,
- Dimelza Araúz,
- Ernesto Morán,
- Maria Chen-Germán,
- Elimelec Valdespino,
- Rita Rodríguez,
- Rita Corrales,
- Roderick Chen-Camaño,
- Juan Miguel Pascale,
- Alexander A. Martínez,
- Sandra López-Vergès
Affiliations
- Yamilka Díaz
- Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama
- Anyuri Ortiz
- Department of Occupational Health, Gorgas Memorial Institute of Health Studies, Panama
- Adriana Weeden
- Unit of Diagnosis, Clinical Research and Tropical Medicine, Gorgas Memorial Institute of Health Studies, Panama
- Daniel Castillo
- Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama
- Claudia González
- Department of Genomic and Proteomic, Gorgas Memorial Institute of Health Studies, Panama
- Brechla Moreno
- Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama
- Mabel Martínez-Montero
- Immunovirology Division, Public Health Reference Central Laboratory, Gorgas Memorial Institute of Health Studies, Panama
- Marlene Castillo
- Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama
- Grettel Vasquez
- Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama
- Lisseth Sáenz
- Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama
- Danilo Franco
- Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama
- Yaneth Pitti
- Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama
- Oris Chavarria
- Department of Genomic and Proteomic, Gorgas Memorial Institute of Health Studies, Panama
- Jessica Gondola
- Department of Genomic and Proteomic, Gorgas Memorial Institute of Health Studies, Panama
- Ambar M. Moreno
- Department of Genomic and Proteomic, Gorgas Memorial Institute of Health Studies, Panama
- Leyda Ábrego
- Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama
- Davis Beltrán
- Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama
- Ilka Guerra
- Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama
- Jim Chang
- Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama
- Zumara Chaverra
- Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama
- Isela Guerrero
- Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama
- Alejandra Valoy
- Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama
- Melissa Gaitán
- Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama
- Dimelza Araúz
- Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama
- Ernesto Morán
- Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama
- Maria Chen-Germán
- Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama
- Elimelec Valdespino
- Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama
- Rita Rodríguez
- Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama
- Rita Corrales
- Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama
- Roderick Chen-Camaño
- Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama
- Juan Miguel Pascale
- Unit of Diagnosis, Clinical Research and Tropical Medicine, Gorgas Memorial Institute of Health Studies, Panama
- Alexander A. Martínez
- Department of Genomic and Proteomic, Gorgas Memorial Institute of Health Studies, Panama; Corresponding author at: Department of Genomic and Proteomic, Gorgas Memorial Institute of Health Studies, Justo Arosemena Avenue and 35th Street, 0816-02593, Panama.
- Sandra López-Vergès
- Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama; Corresponding author at: Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Justo Arosemena Avenue and 35th Street, 0816-02593, Panama.
- Journal volume & issue
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Vol. 108
pp. 588 – 591
Abstract
We report a case of reinfection by SARS-CoV-2 with the second virus harboring amino acid changes in the Spike protein (141-143del, D215A, ins215AGY, L452R, D614G), orf1a, helicase, orf3a, and Nucleocapside. The virus associated with the reinfection, from an endemic lineage containing the S:L452R immune escape mutation, was circulating in Panama at the time.
