Development of a Promising Method for Producing Oligomeric Mixture of Branched Alkylene Guanidines to Improve Substance Quality and Evaluate Their Antiviral Activity against SARS-CoV-2
Denis O. Shatalov,
Stanislav A. Kedik,
Ivan S. Ivanov,
Anna V. Aydakova,
Diana A. Akhmedova,
Dmitrii S. Minenkov,
Sergei V. Beliakov,
Alexander Herbst,
Lasse Greiner,
Liubov I. Kozlovskaya,
Viktor P. Volok
Affiliations
Denis O. Shatalov
Institute of Fine Chemical Technologies Named after Lomonosov, MIREA—Russian Technological University, 119571 Moscow, Russia
Stanislav A. Kedik
Institute of Fine Chemical Technologies Named after Lomonosov, MIREA—Russian Technological University, 119571 Moscow, Russia
Ivan S. Ivanov
Institute of Fine Chemical Technologies Named after Lomonosov, MIREA—Russian Technological University, 119571 Moscow, Russia
Anna V. Aydakova
Institute of Fine Chemical Technologies Named after Lomonosov, MIREA—Russian Technological University, 119571 Moscow, Russia
Diana A. Akhmedova
Institute of Fine Chemical Technologies Named after Lomonosov, MIREA—Russian Technological University, 119571 Moscow, Russia
Dmitrii S. Minenkov
Ishlinsky Institute for Problems in Mechanics RAS, 119526 Moscow, Russia
Sergei V. Beliakov
Institute of Fine Chemical Technologies Named after Lomonosov, MIREA—Russian Technological University, 119571 Moscow, Russia
Alexander Herbst
Wingflow AG, Gaensaker 5, 5070 Frick, Switzerland
Lasse Greiner
Mannheim University of Applied Sciences, 68163 Mannheim, Germany
Liubov I. Kozlovskaya
FSBSI “Chumakov FSC R&D IBP RAS”, 108819 Moscow, Russia
Viktor P. Volok
FSBSI “Chumakov FSC R&D IBP RAS”, 108819 Moscow, Russia
This paper reports the synthesis of branched alkylene guanidines using microfluidic technologies. We describe the preparation of guanidine derivatives at lower temperatures, and with significantly less time than that required in the previously applicable method. Furthermore, the use of microfluidics allows the attainment of high-purity products with a low residual monomer content, which can expand the range of applications of this class of compounds. For all the samples obtained, the molecular-weight characteristics are calculated, based on which the optimal condensation conditions are established. Additionally, in this work, the antiviral activity of the alkylene guanidine salt against the SARS-CoV-2 virus is confirmed.
