Nature Communications (Nov 2018)

Diffusion-limited association of disordered protein by non-native electrostatic interactions

  • Jae-Yeol Kim,
  • Fanjie Meng,
  • Janghyun Yoo,
  • Hoi Sung Chung

DOI
https://doi.org/10.1038/s41467-018-06866-y
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

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Intrinsically disordered proteins (IDPs) usually fold during binding to target proteins which involves the formation of a transient complex (TC). Here authors use single-molecule FRET to show that the lifetime of TC for IDP binding is very long due to the stabilization by non-native electrostatic interactions, which makes fast association possible.