Nature Communications (Nov 2018)
Diffusion-limited association of disordered protein by non-native electrostatic interactions
Abstract
Intrinsically disordered proteins (IDPs) usually fold during binding to target proteins which involves the formation of a transient complex (TC). Here authors use single-molecule FRET to show that the lifetime of TC for IDP binding is very long due to the stabilization by non-native electrostatic interactions, which makes fast association possible.