Concerted dynamics of metallo-base pairs in an A/B-form helical transition

Olivia P. Schmidt; Simon Jurt; Silke Johannsen; Ashkan Karimi; Roland K. O. Sigel; Nathan W. Luedtke

doi:10.1038/s41467-019-12440-x

Nature Communications (Oct 2019)

Concerted dynamics of metallo-base pairs in an A/B-form helical transition

Olivia P. Schmidt,
Simon Jurt,
Silke Johannsen,
Ashkan Karimi,
Roland K. O. Sigel,
Nathan W. Luedtke

Affiliations

Olivia P. Schmidt: Department of Chemistry, University of Zurich
Simon Jurt: Department of Chemistry, University of Zurich
Silke Johannsen: Department of Chemistry, University of Zurich
Ashkan Karimi: Department of Chemistry, University of Zurich
Roland K. O. Sigel: Department of Chemistry, University of Zurich
Nathan W. Luedtke: Department of Chemistry, University of Zurich

DOI: https://doi.org/10.1038/s41467-019-12440-x
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

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Metal-mediated base pairs expand the repertoire of nucleic acid structures and dynamics. Here, the authors prepared a metallo-DNA duplex including two C-Hg(II)-T base pairs separated by six normal Watson-Crick base pairs and investigated its solution structure and dynamics using NMR spectroscopy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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