Peculiarities of the expression of regulatory protein titin and collagen I in myocardium of spontaneously hypertensive rats with experimental diabetes mellitus

Abstract

Possible pathogenetic mechanisms of diastolic dysfunction formation in arterial hypertension with concomitant diabetes mellitus were investigated. The morphological basis of increased myocardial stiffness was studied on the model of spontaneously hypertensive rats with experimental diabetes mellitus. The expression of cardiac titin as myocardial elastic properties regulator and its association with level of cardiac fi brosis were examined. It was found that total titin content was reduced by 27 % compared with intact hypertensive rats. These changes were associated with the progression of cardiac fi brosis, which was confi rmed by 2,5-fold increased level of collagen I expression.

Keywords

• titin
• collagen I
• myocardium
• experimental diabetes mellitus
• spontaneously hypertensive rats.