Nature Communications (Feb 2019)
Intestinal non-canonical NFκB signaling shapes the local and systemic immune response
- Sadeesh K. Ramakrishnan,
- Huabing Zhang,
- Xiaoya Ma,
- Inkyung Jung,
- Andrew J. Schwartz,
- Daniel Triner,
- Samantha N. Devenport,
- Nupur K. Das,
- Xiang Xue,
- Melody Y. Zeng,
- Yinling Hu,
- Richard M. Mortensen,
- Joel K Greenson,
- Marilia Cascalho,
- Christiane E. Wobus,
- Justin A. Colacino,
- Gabriel Nunez,
- Liangyou Rui,
- Yatrik M. Shah
Affiliations
- Sadeesh K. Ramakrishnan
- Department of Medicine, University of Pittsburgh
- Huabing Zhang
- Department of Molecular & Integrative Physiology, University of Michigan
- Xiaoya Ma
- Department of Molecular & Integrative Physiology, University of Michigan
- Inkyung Jung
- Department of Molecular & Integrative Physiology, University of Michigan
- Andrew J. Schwartz
- Department of Molecular & Integrative Physiology, University of Michigan
- Daniel Triner
- Department of Molecular & Integrative Physiology, University of Michigan
- Samantha N. Devenport
- Department of Molecular & Integrative Physiology, University of Michigan
- Nupur K. Das
- Department of Molecular & Integrative Physiology, University of Michigan
- Xiang Xue
- Department of Molecular & Integrative Physiology, University of Michigan
- Melody Y. Zeng
- Department of Pathology, University of Michigan
- Yinling Hu
- Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Richard M. Mortensen
- Department of Molecular & Integrative Physiology, University of Michigan
- Joel K Greenson
- Department of Pathology, University of Michigan
- Marilia Cascalho
- Transplantation Biology, University of Michigan
- Christiane E. Wobus
- Department of Microbiology and Immunology, University of Michigan
- Justin A. Colacino
- Department of Environmental Health Sciences, University of Michigan
- Gabriel Nunez
- Department of Pathology, University of Michigan
- Liangyou Rui
- Department of Molecular & Integrative Physiology, University of Michigan
- Yatrik M. Shah
- Department of Molecular & Integrative Physiology, University of Michigan
- DOI
- https://doi.org/10.1038/s41467-019-08581-8
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
Microfold cells (M-cell) are specialized cells of the intestine that sample luminal microbiota and dietary antigens. Here the authors show that epithelial non-canonical NFκB signalling, as induced by NIK, is important for M-cells maintenance, yet constitutive NIK activation is associated with gut inflammation and inflammatory bowel disease.
