Insulin-Like Growth Factor-1: A Promising Therapeutic Target for Peripheral Nerve Injury

Benjamin R. Slavin; Benjamin R. Slavin; Karim A. Sarhane; Nicholas von Guionneau; Phillip J. Hanwright; Chenhu Qiu; Chenhu Qiu; Hai-Quan Mao; Hai-Quan Mao; Hai-Quan Mao; Hai-Quan Mao; Ahmet Höke; Ahmet Höke; Sami H. Tuffaha

doi:10.3389/fbioe.2021.695850

Frontiers in Bioengineering and Biotechnology (Jun 2021)

Insulin-Like Growth Factor-1: A Promising Therapeutic Target for Peripheral Nerve Injury

Benjamin R. Slavin,
Benjamin R. Slavin,
Karim A. Sarhane,
Nicholas von Guionneau,
Phillip J. Hanwright,
Chenhu Qiu,
Chenhu Qiu,
Hai-Quan Mao,
Hai-Quan Mao,
Hai-Quan Mao,
Hai-Quan Mao,
Ahmet Höke,
Ahmet Höke,
Sami H. Tuffaha

Affiliations

Benjamin R. Slavin: Department of Plastic and Reconstructive Surgery, School of Medicine, Johns Hopkins University, Baltimore, MD, United States
Benjamin R. Slavin: Division of Plastic and Reconstructive Surgery, University of Miami Miller School of Medicine, Miami, FL, United States
Karim A. Sarhane: Department of Plastic and Reconstructive Surgery, School of Medicine, Johns Hopkins University, Baltimore, MD, United States
Nicholas von Guionneau: Department of Plastic and Reconstructive Surgery, School of Medicine, Johns Hopkins University, Baltimore, MD, United States
Phillip J. Hanwright: Department of Plastic and Reconstructive Surgery, School of Medicine, Johns Hopkins University, Baltimore, MD, United States
Chenhu Qiu: Department of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, United States
Chenhu Qiu: Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD, United States
Hai-Quan Mao: Department of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, United States
Hai-Quan Mao: Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD, United States
Hai-Quan Mao: Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD, United States
Hai-Quan Mao: Translational Tissue Engineering Center, School of Medicine, Johns Hopkins University, Baltimore, MD, United States
Ahmet Höke: Department of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, United States
Ahmet Höke: Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD, United States
Sami H. Tuffaha: Department of Plastic and Reconstructive Surgery, School of Medicine, Johns Hopkins University, Baltimore, MD, United States

DOI: https://doi.org/10.3389/fbioe.2021.695850
Journal volume & issue: Vol. 9

Abstract

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Patients who sustain peripheral nerve injuries (PNIs) are often left with debilitating sensory and motor loss. Presently, there is a lack of clinically available therapeutics that can be given as an adjunct to surgical repair to enhance the regenerative process. Insulin-like growth factor-1 (IGF-1) represents a promising therapeutic target to meet this need, given its well-described trophic and anti-apoptotic effects on neurons, Schwann cells (SCs), and myocytes. Here, we review the literature regarding the therapeutic potential of IGF-1 in PNI. We appraised the literature for the various approaches of IGF-1 administration with the aim of identifying which are the most promising in offering a pathway toward clinical application. We also sought to determine the optimal reported dosage ranges for the various delivery approaches that have been investigated.

Published in Frontiers in Bioengineering and Biotechnology

ISSN: 2296-4185 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Technology: Chemical technology: Biotechnology
Website: http://www.frontiersin.org/bioengineering_and_biotechnology

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Abstract

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