Journal of Translational Medicine (Jun 2010)

Adipose-derived mesenchymal stem cells markedly attenuate brain infarct size and improve neurological function in rats

  • Sun Cheuk-Kwan,
  • Kao Ying-Hsien,
  • Yen Chia-Hung,
  • Yuen Chun-Man,
  • Lin Yu-Chun,
  • Leu Steve,
  • Yip Hon-Kan

DOI
https://doi.org/10.1186/1479-5876-8-63
Journal volume & issue
Vol. 8, no. 1
p. 63

Abstract

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Abstract Background The therapeutic effect of adipose-derived mesenchymal stem cells (ADMSCs) on brain infarction area (BIA) and neurological status in a rat model of acute ischemic stroke (IS) was investigated. Methods Adult male Sprague-Dawley (SD) rats (n = 30) were divided into IS plus intra-venous 1 mL saline (at 0, 12 and 24 h after IS induction) (control group) and IS plus intra-venous ADMSCs (2.0 × 106) (treated interval as controls) (treatment group) after occlusion of distal left internal carotid artery. The rats were sacrificed and brain tissues were harvested on day 21 after the procedure. Results The results showed that BIA was larger in control group than in treatment group (p Conclusions ADMSC therapy significantly limited BIA and improved sensorimotor dysfunction after acute IS.