Nature Communications (Nov 2019)

RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2

  • Barbara Nicol,
  • Sara A. Grimm,
  • Frédéric Chalmel,
  • Estelle Lecluze,
  • Maëlle Pannetier,
  • Eric Pailhoux,
  • Elodie Dupin-De-Beyssat,
  • Yann Guiguen,
  • Blanche Capel,
  • Humphrey H.-C. Yao

DOI
https://doi.org/10.1038/s41467-019-13060-1
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

Read online

Proper ovarian differentiation requires RUNX1. Here, the authors show that double knockout of Runx1/Foxl2 results in masculinization of fetal ovaries, and that RUNX1 and FOXL2 jointly occupy common chromatin regions to maintain pre-granulosa cell identity in the fetal ovary.