Nature Communications (Nov 2019)
An MPER antibody neutralizes HIV-1 using germline features shared among donors
- Lei Zhang,
- Adriana Irimia,
- Lingling He,
- Elise Landais,
- Kimmo Rantalainen,
- Daniel P. Leaman,
- Thomas Vollbrecht,
- Armando Stano,
- Daniel I. Sands,
- Arthur S. Kim,
- IAVI Protocol G Investigators,
- Pascal Poignard,
- Dennis R. Burton,
- Ben Murrell,
- Andrew B. Ward,
- Jiang Zhu,
- Ian A. Wilson,
- Michael B. Zwick
Affiliations
- Lei Zhang
- Department of Immunology and Microbiology, The Scripps Research Institute
- Adriana Irimia
- Department of Integrative Structural and Computational Biology, The Scripps Research Institute
- Lingling He
- Department of Immunology and Microbiology, The Scripps Research Institute
- Elise Landais
- Department of Immunology and Microbiology, The Scripps Research Institute
- Kimmo Rantalainen
- Department of Integrative Structural and Computational Biology, The Scripps Research Institute
- Daniel P. Leaman
- Department of Immunology and Microbiology, The Scripps Research Institute
- Thomas Vollbrecht
- Department of Medicine, University of California
- Armando Stano
- Department of Immunology and Microbiology, The Scripps Research Institute
- Daniel I. Sands
- Department of Immunology and Microbiology, The Scripps Research Institute
- Arthur S. Kim
- Department of Immunology and Microbiology, The Scripps Research Institute
- IAVI Protocol G Investigators
- Pascal Poignard
- Department of Immunology and Microbiology, The Scripps Research Institute
- Dennis R. Burton
- Department of Immunology and Microbiology, The Scripps Research Institute
- Ben Murrell
- Department of Medicine, University of California
- Andrew B. Ward
- Department of Integrative Structural and Computational Biology, The Scripps Research Institute
- Jiang Zhu
- Department of Immunology and Microbiology, The Scripps Research Institute
- Ian A. Wilson
- Department of Integrative Structural and Computational Biology, The Scripps Research Institute
- Michael B. Zwick
- Department of Immunology and Microbiology, The Scripps Research Institute
- DOI
- https://doi.org/10.1038/s41467-019-12973-1
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
Here, the authors identify a broadly neutralizing antibody from an HIV-infected person that recognizes the membrane-proximal external region (MPER) of HIV envelope glycoprotein (Env) and has a short CDRH3 and low polyreactivity. Structural analysis shows how the antibody binds the MPER and Env on the viral membrane.
