Frontiers in Psychiatry (Mar 2019)
The Therapeutic Potential of Mangosteen Pericarp as an Adjunctive Therapy for Bipolar Disorder and Schizophrenia
- Melanie M. Ashton,
- Melanie M. Ashton,
- Melanie M. Ashton,
- Olivia M. Dean,
- Olivia M. Dean,
- Olivia M. Dean,
- Adam J. Walker,
- Chiara C. Bortolasci,
- Chee H. Ng,
- Malcolm Hopwood,
- Brian H. Harvey,
- Marisa Möller,
- John J. McGrath,
- John J. McGrath,
- John J. McGrath,
- Wolfgang Marx,
- Alyna Turner,
- Alyna Turner,
- Seetal Dodd,
- Seetal Dodd,
- Seetal Dodd,
- James G. Scott,
- James G. Scott,
- James G. Scott,
- Jon-Paul Khoo,
- Jon-Paul Khoo,
- Ken Walder,
- Jerome Sarris,
- Jerome Sarris,
- Michael Berk,
- Michael Berk,
- Michael Berk,
- Michael Berk,
- Michael Berk
Affiliations
- Melanie M. Ashton
- IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, VIC, Australia
- Melanie M. Ashton
- Florey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia
- Melanie M. Ashton
- Professorial Unit, The Melbourne Clinic, Department of Psychiatry, University of Melbourne, Richmond, VIC, Australia
- Olivia M. Dean
- IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, VIC, Australia
- Olivia M. Dean
- Florey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia
- Olivia M. Dean
- Department of Psychiatry, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia
- Adam J. Walker
- IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, VIC, Australia
- Chiara C. Bortolasci
- Centre for Molecular and Medical Research, School of Medicine, Deakin University, Geelong, VIC, Australia
- Chee H. Ng
- Professorial Unit, The Melbourne Clinic, Department of Psychiatry, University of Melbourne, Richmond, VIC, Australia
- Malcolm Hopwood
- Professorial Psychiatry Unit, Albert Road Clinic, University of Melbourne, Melbourne, VIC, Australia
- Brian H. Harvey
- Centre of Excellence for Pharmaceutical Sciences, School of Pharmacy (Pharmacology), North West University, Potchefstroom, South Africa
- Marisa Möller
- Centre of Excellence for Pharmaceutical Sciences, School of Pharmacy (Pharmacology), North West University, Potchefstroom, South Africa
- John J. McGrath
- Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, QLD, Australia
- John J. McGrath
- Queensland Brain Institute, University of Queensland, St. Lucia, QLD, Australia
- John J. McGrath
- 0National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark
- Wolfgang Marx
- IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, VIC, Australia
- Alyna Turner
- IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, VIC, Australia
- Alyna Turner
- Department of Psychiatry, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia
- Seetal Dodd
- IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, VIC, Australia
- Seetal Dodd
- Department of Psychiatry, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia
- Seetal Dodd
- 1Centre of Youth Mental Health, University of Melbourne, Parkville, VIC, Australia
- James G. Scott
- Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, QLD, Australia
- James G. Scott
- 2Faculty of Medicine, The University of Queensland, Herston, QLD, Australia
- James G. Scott
- 3Metro North Mental Health, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia
- Jon-Paul Khoo
- IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, VIC, Australia
- Jon-Paul Khoo
- 2Faculty of Medicine, The University of Queensland, Herston, QLD, Australia
- Ken Walder
- Centre for Molecular and Medical Research, School of Medicine, Deakin University, Geelong, VIC, Australia
- Jerome Sarris
- Professorial Unit, The Melbourne Clinic, Department of Psychiatry, University of Melbourne, Richmond, VIC, Australia
- Jerome Sarris
- 4NICM Health Research Institute, Western Sydney University, Westmead, NSW, Australia
- Michael Berk
- IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, VIC, Australia
- Michael Berk
- Florey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia
- Michael Berk
- Department of Psychiatry, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia
- Michael Berk
- 1Centre of Youth Mental Health, University of Melbourne, Parkville, VIC, Australia
- Michael Berk
- 5Orygen Youth Health Research Centre, Parkville, VIC, Australia
- DOI
- https://doi.org/10.3389/fpsyt.2019.00115
- Journal volume & issue
-
Vol. 10
Abstract
New treatments are urgently needed for serious mental illnesses including bipolar disorder and schizophrenia. This review proposes that Garcinia mangostana Linn. (mangosteen) pericarp is a possible adjunctive therapeutic agent for these disorders. Research to date demonstrates that neurobiological properties of the mangosteen pericarp are well aligned with the current understanding of the pathophysiology of bipolar disorder and schizophrenia. Mangosteen pericarp has antioxidant, putative neuroprotective, anti-inflammatory, and putative mitochondrial enhancing properties, with animal studies demonstrating favorable pharmacotherapeutic benefits with respect to these disorders. This review summarizes evidence of its properties and supports the case for future studies to assess the utility of mangosteen pericarp as an adjunctive treatment option for mood and psychotic disorders.
Keywords
