The ZZ-type zinc finger of ZZZ3 modulates the ATAC complex-mediated histone acetylation and gene activation

Wenyi Mi; Yi Zhang; Jie Lyu; Xiaolu Wang; Qiong Tong; Danni Peng; Yongming Xue; Adam H. Tencer; Hong Wen; Wei Li; Tatiana G. Kutateladze; Xiaobing Shi

doi:10.1038/s41467-018-06247-5

Nature Communications (Sep 2018)

The ZZ-type zinc finger of ZZZ3 modulates the ATAC complex-mediated histone acetylation and gene activation

Wenyi Mi,
Yi Zhang,
Jie Lyu,
Xiaolu Wang,
Qiong Tong,
Danni Peng,
Yongming Xue,
Adam H. Tencer,
Hong Wen,
Wei Li,
Tatiana G. Kutateladze,
Xiaobing Shi

Affiliations

Wenyi Mi: Department of Epigenetics and Molecular Carcinogenesis, Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center
Yi Zhang: Department of Pharmacology, University of Colorado School of Medicine
Jie Lyu: Dan L. Duncan Cancer Center, Department of Molecular and Cellular Biology, Baylor College of Medicine
Xiaolu Wang: Department of Epigenetics and Molecular Carcinogenesis, Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center
Qiong Tong: Department of Pharmacology, University of Colorado School of Medicine
Danni Peng: Department of Epigenetics and Molecular Carcinogenesis, Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center
Yongming Xue: Department of Epigenetics and Molecular Carcinogenesis, Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center
Adam H. Tencer: Department of Pharmacology, University of Colorado School of Medicine
Hong Wen: Department of Epigenetics and Molecular Carcinogenesis, Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center
Wei Li: Dan L. Duncan Cancer Center, Department of Molecular and Cellular Biology, Baylor College of Medicine
Tatiana G. Kutateladze: Department of Pharmacology, University of Colorado School of Medicine
Xiaobing Shi: Department of Epigenetics and Molecular Carcinogenesis, Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center

DOI: https://doi.org/10.1038/s41467-018-06247-5
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 9

Abstract

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Histones are recognized by epigenetic readers, which play essential roles in regulation of chromatin and transcription. Here the authors provide evidence that the ZZ-type zinc finger domain of ZZZ3 functions as a reader of histone H3, which is required for the ATAC complex-mediated maintenance of histone acetylation and gene activation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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