Uji Efek Antiinflamasi Fraksi Air Daun Mahkota Dewa (Phaleria macrocarpa (Shecff.) Boerl.) terhadap Tikus Putih (Rattus norvegicus L.)

Abstract

Inflammation occurs as the attempt of body to inactivate organisms that attack the body, to remove irritants and to regulate tissue repair. One of the medicinal plants used empirically as antiinflammation is the leaf of Mahkota Dewa (Phaleria macrocarpa (Schecff.) Boerl). This study investigated the effect of anti-inflammatory water fraction of Mahkota Dewa leaf using oedema induction method with caragenin in rat. Water fraction of Mahkota Dewa leaf was given at the dose of 0.5 g/kg BW, 1 g/kg BW and 2 g/kg BW. Sodium diclofenac was used as a positive control and CMC as a negative control. The result showed that water fractions of the three doses could inhibit inflammation at 27.35%, 18.58%, and 20.17%, respectively. The water fraction at the dose of 0.5 g/kgBW showed the largest percentage of oedema inhibition compared to the other treatment groups.

Keywords

• Antiinflammation
• water fraction of leave Phaleria macrocarpa (Schecff.) Boerl.
• oedema
• antiinflamasi
• fraksi air daun Phaleria macrocarpa (Schecff.) Boerl.
• udem