Nature Communications (May 2019)
The viral protein corona directs viral pathogenesis and amyloid aggregation
- Kariem Ezzat,
- Maria Pernemalm,
- Sandra Pålsson,
- Thomas C. Roberts,
- Peter Järver,
- Aleksandra Dondalska,
- Burcu Bestas,
- Michal J. Sobkowiak,
- Bettina Levänen,
- Magnus Sköld,
- Elizabeth A. Thompson,
- Osama Saher,
- Otto K. Kari,
- Tatu Lajunen,
- Eva Sverremark Ekström,
- Caroline Nilsson,
- Yevheniia Ishchenko,
- Tarja Malm,
- Matthew J. A. Wood,
- Ultan F. Power,
- Sergej Masich,
- Anders Lindén,
- Johan K. Sandberg,
- Janne Lehtiö,
- Anna-Lena Spetz,
- Samir EL Andaloussi
Affiliations
- Kariem Ezzat
- Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
- Maria Pernemalm
- Clinical Proteomics Mass Spectrometry, Department of Oncology-Pathology, Science for Life Laboratory and Karolinska Institutet
- Sandra Pålsson
- Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
- Thomas C. Roberts
- Department of Physiology, Anatomy and Genetics, University of Oxford
- Peter Järver
- Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
- Aleksandra Dondalska
- Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
- Burcu Bestas
- Department of Laboratory Medicine, Clinical Research Center, Karolinska Institutet
- Michal J. Sobkowiak
- Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge
- Bettina Levänen
- Unit for Lung and Airway disease, Institute of Environmental Medicine, Karolinska Institutet
- Magnus Sköld
- Respiratory Medicine Unit, Department of Medicine, Karolinska Institutet
- Elizabeth A. Thompson
- Immunology and Allergy Unit, and Center for Molecular Medicine, Department of Medicine, Karolinska Institutet
- Osama Saher
- Department of Laboratory Medicine, Clinical Research Center, Karolinska Institutet
- Otto K. Kari
- Drug Research Program, Faculty of Pharmacy, Division of Pharmaceutical Biosciences, University of Helsinki
- Tatu Lajunen
- Drug Research Program, Faculty of Pharmacy, Division of Pharmaceutical Biosciences, University of Helsinki
- Eva Sverremark Ekström
- Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
- Caroline Nilsson
- Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet and Sachs’ Children and Youth Hospital
- Yevheniia Ishchenko
- A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland
- Tarja Malm
- A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland
- Matthew J. A. Wood
- Department of Physiology, Anatomy and Genetics, University of Oxford
- Ultan F. Power
- Centre of Experimental Medicine, Queens’ University Belfast
- Sergej Masich
- Department of Cell and Molecular Biology, Karolinska Institutet
- Anders Lindén
- Unit for Lung and Airway disease, Institute of Environmental Medicine, Karolinska Institutet
- Johan K. Sandberg
- Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge
- Janne Lehtiö
- Clinical Proteomics Mass Spectrometry, Department of Oncology-Pathology, Science for Life Laboratory and Karolinska Institutet
- Anna-Lena Spetz
- Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
- Samir EL Andaloussi
- Department of Laboratory Medicine, Clinical Research Center, Karolinska Institutet
- DOI
- https://doi.org/10.1038/s41467-019-10192-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
The protein corona around artificial nanoparticles is known to influence activity and biological fate, the formation around viruses is less well understood. Here, the authors observe the formation of protein corona on viruses and study the effects this corona has on viral infectivity and on amyloid protein assembly.
