Nature Communications (Feb 2024)
Demographic and Clinical Factors Associated With SARS-CoV-2 Spike 1 Antibody Response Among Vaccinated US Adults: the C4R Study
- John S. Kim,
- Yifei Sun,
- Pallavi Balte,
- Mary Cushman,
- Rebekah Boyle,
- Russell P. Tracy,
- Linda M. Styer,
- Taison D. Bell,
- Michaela R. Anderson,
- Norrina B. Allen,
- Pamela J. Schreiner,
- Russell P. Bowler,
- David A. Schwartz,
- Joyce S. Lee,
- Vanessa Xanthakis,
- Margaret F. Doyle,
- Elizabeth A. Regan,
- Barry J. Make,
- Alka M. Kanaya,
- Sally E. Wenzel,
- Josef Coresh,
- Carmen R. Isasi,
- Laura M. Raffield,
- Mitchell S. V. Elkind,
- Virginia J. Howard,
- Victor E. Ortega,
- Prescott Woodruff,
- Shelley A. Cole,
- Joel M. Henderson,
- Nicholas J. Mantis,
- Monica M. Parker,
- Ryan T. Demmer,
- Elizabeth C. Oelsner
Affiliations
- John S. Kim
- Department of Medicine, University of Virginia School of Medicine
- Yifei Sun
- Department of Biostatistics, Columbia University Mailman School of Public Health
- Pallavi Balte
- Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons
- Mary Cushman
- Department of Medicine, Larner College of Medicine at the University of Vermont
- Rebekah Boyle
- Department of Pathology and Laboratory Medicine, Larner College of Medicine at the University of Vermont
- Russell P. Tracy
- Department of Pathology and Laboratory Medicine, Larner College of Medicine at the University of Vermont
- Linda M. Styer
- Division of Infectious Diseases, Wadsworth Center, New York State Department of Health
- Taison D. Bell
- Department of Medicine, University of Virginia School of Medicine
- Michaela R. Anderson
- Department of Medicine, University of Pennsylvania
- Norrina B. Allen
- Department of Preventive Medicine, Northwestern University Feinberg School of Medicine
- Pamela J. Schreiner
- Division of Epidemiology and Community Health, School of Public Health, University of Minnesota
- Russell P. Bowler
- Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health
- David A. Schwartz
- Department of Medicine, University of Colorado School of Medicine
- Joyce S. Lee
- Department of Medicine, University of Colorado School of Medicine
- Vanessa Xanthakis
- Department of Medicine, Boston University Chobanian and Avedisian School of Medicine
- Margaret F. Doyle
- Department of Pathology and Laboratory Medicine, Larner College of Medicine at the University of Vermont
- Elizabeth A. Regan
- Division of Rheumatology, National Jewish Health
- Barry J. Make
- Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health
- Alka M. Kanaya
- Division of General Internal Medicine, University of California San Francisco
- Sally E. Wenzel
- Department of Medicine, Department of Immunology, and Department of Environmental Medicine and Occupational Health, University of Pittsburgh School of Medicine, School of Public Health
- Josef Coresh
- Department of Population Health, New York University Grossman School of Medicine, New York University Langone Health
- Carmen R. Isasi
- Department of Epidemiology and Population Health, Albert Einstein College of Medicine
- Laura M. Raffield
- Department of Genetics, University of North Carolina
- Mitchell S. V. Elkind
- Department of Neurology, Columbia University Vagelos College of Physicians and Surgeons
- Virginia J. Howard
- Department of Epidemiology, School of Public Health, University of Alabama at Birmingham
- Victor E. Ortega
- Division of Respiratory Medicine, Mayo Clinic
- Prescott Woodruff
- Division of Pulmonary and Critical Care Medicine, University of California San Francisco
- Shelley A. Cole
- Population Health Program, Texas Biomedical Research Institute
- Joel M. Henderson
- Department of Pathology and Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine and Boston Medical Center
- Nicholas J. Mantis
- Division of Infectious Diseases, Wadsworth Center, New York State Department of Health
- Monica M. Parker
- Division of Infectious Diseases, Wadsworth Center, New York State Department of Health
- Ryan T. Demmer
- Division of Epidemiology and Community Health, School of Public Health, University of Minnesota
- Elizabeth C. Oelsner
- Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons
- DOI
- https://doi.org/10.1038/s41467-024-45468-9
- Journal volume & issue
-
Vol. 15,
no. 1
pp. 1 – 12
Abstract
Abstract This study investigates correlates of anti-S1 antibody response following COVID-19 vaccination in a U.S. population-based meta-cohort of adults participating in longstanding NIH-funded cohort studies. Anti-S1 antibodies were measured from dried blood spots collected between February 2021-August 2022 using Luminex-based microsphere immunoassays. Of 6245 participants, mean age was 73 years (range, 21-100), 58% were female, and 76% were non-Hispanic White. Nearly 52% of participants received the BNT162b2 vaccine and 48% received the mRNA-1273 vaccine. Lower anti-S1 antibody levels are associated with age of 65 years or older, male sex, higher body mass index, smoking, diabetes, COPD and receipt of BNT16b2 vaccine (vs mRNA-1273). Participants with a prior infection, particularly those with a history of hospitalized illness, have higher anti-S1 antibody levels. These results suggest that adults with certain socio-demographic and clinical characteristics may have less robust antibody responses to COVID-19 vaccination and could be prioritized for more frequent re-vaccination.
