Materials Research Letters (Jun 2020)

Effect of surface grain boundary density on preosteoblast proliferation on titanium

  • Terry C. Lowe,
  • Rebecca A. Reiss,
  • Patrick E. Illescas,
  • Casey F. Davis,
  • Melanie C. Connick,
  • Johnny A. Sena

DOI
https://doi.org/10.1080/21663831.2020.1744758
Journal volume & issue
Vol. 8, no. 6
pp. 239 – 246

Abstract

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Studies since 2004 have shown that the cytocompatibility of ultrafine grain (UG) commercial purity (CP) titanium exceeds that of coarse grain (CG) CP titanium (Ti) by 30% to 20-fold. To isolate the factors affecting this large reported variability of CP titanium’s cytocompatibility, discs of UG and CG titanium were fabricated with controlled texture and roughness. The discs were seeded with MC3T3-E1 pre-osteoblastic cells and cultured for 72 h. The proliferation of cells on polished UG-Ti exceeded unpolished CG-Ti 3.04-fold. Cell proliferation was found to correlate with a new biophysical parameter, the average grain boundary length per surface-attached cell.

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