Nature Communications (Aug 2021)
A comprehensive risk score for effective risk stratification and screening of nasopharyngeal carcinoma
- Xiang Zhou,
- Su-Mei Cao,
- Yong-Lin Cai,
- Xiao Zhang,
- Shanshan Zhang,
- Guo-Fei Feng,
- Yufeng Chen,
- Qi-Sheng Feng,
- Yijun Chen,
- Ellen T. Chang,
- Zhonghua Liu,
- Hans-Olov Adami,
- Jianjun Liu,
- Weimin Ye,
- Zhe Zhang,
- Yi-Xin Zeng,
- Miao Xu
Affiliations
- Xiang Zhou
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center
- Su-Mei Cao
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center
- Yong-Lin Cai
- Department of Clinical Laboratory, Wuzhou Red Cross Hospital
- Xiao Zhang
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center
- Shanshan Zhang
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center
- Guo-Fei Feng
- Department of Otolaryngology/Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University
- Yufeng Chen
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Qi-Sheng Feng
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center
- Yijun Chen
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center
- Ellen T. Chang
- Center for Health Sciences, Exponent
- Zhonghua Liu
- Department of Statistics and Actuarial Science, The University of Hong Kong
- Hans-Olov Adami
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Jianjun Liu
- Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR)
- Weimin Ye
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Zhe Zhang
- Department of Otolaryngology/Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University
- Yi-Xin Zeng
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center
- Miao Xu
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center
- DOI
- https://doi.org/10.1038/s41467-021-25402-z
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 8
Abstract
Epstein-Barr virus (EBV) is associated with high risk for nasopharyngeal carcinoma (NPC). Here, the authors develop a comprehensive risk score that combines risk effects of EBV and human genetics for NPC risk stratification.
