Journal of Cleft Lip Palate and Craniofacial Anomalies (Jan 2015)

Consanguinity and clefts in the craniofacial region: A retrospective case-control study

  • Betty Anna Jose,
  • Subramani Arumugam Subramani,
  • Varsha Mokhasi,
  • Mini Jayan

DOI
https://doi.org/10.4103/2348-2125.162965
Journal volume & issue
Vol. 2, no. 2
pp. 113 – 117

Abstract

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Objective: The objective was to investigate the association between consanguinity and clefts in the craniofacial region. Materials and Methods: Sample consists of 179 non-syndromic cases of clefts in the craniofacial region and 200 healthy controls with no cleft or family history of clefting. A standardized questionnaire was prepared to investigate the information on the demographic characteristics and consanguinity. Chi-square and odds ratio were used to evaluate the risk of consanguinity in clefts in the craniofacial region. Results: There is a significant association between consanguinity and clefts (P = 0.001) when comparing the consanguinity and no consanguinity in cleft group and non-cleft group, and the association is more with the second degree consanguinity than the third degree consanguinity. Conclusion: Consanguinity is a risk factor for clefts in the craniofacial region.

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