The mixed effect of Endocrine-Disrupting chemicals on biological age Acceleration: Unveiling the mechanism and potential intervention target

Weichao Huang; Zilong Zhang; Manuel Colucci; Linghui Deng; Mi Yang; Xinyi Huang; Xianghong Zhou; Yumin Jin; Edoardo Lazzarini; Carolina Balbi; Oriol Juanola; Aurora Valdata; Silvia Bressan; Yu Zhan; Fang Qi; Qiang Wei; Lu Yang; Xiaoli Zou; Shi Qiu

Environment International (Feb 2024)

The mixed effect of Endocrine-Disrupting chemicals on biological age Acceleration: Unveiling the mechanism and potential intervention target

Weichao Huang,
Zilong Zhang,
Manuel Colucci,
Linghui Deng,
Mi Yang,
Xinyi Huang,
Xianghong Zhou,
Yumin Jin,
Edoardo Lazzarini,
Carolina Balbi,
Oriol Juanola,
Aurora Valdata,
Silvia Bressan,
Yu Zhan,
Fang Qi,
Qiang Wei,
Lu Yang,
Xiaoli Zou,
Shi Qiu

Affiliations

Weichao Huang: Department of Urology and Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China; National Clinical Research Center of Geriatrics, The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Zilong Zhang: Department of Urology and Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China; National Clinical Research Center of Geriatrics, The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Manuel Colucci: Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland (IOSI), CH6500 Bellinzona, Switzerland; Università della Svizzera Italiana, CH6900 Lugano, Switzerland; Faculty of Biology and Medicine, University of Lausanne UNIL, CH1011 Lausanne, Switzerland
Linghui Deng: National Clinical Research Center of Geriatrics, The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, China; Department of Gerontology, West China Hospital of Sichuan University, Chengdu, China
Mi Yang: Department of Sanitary Technology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China
Xinyi Huang: Department of Sanitary Technology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China
Xianghong Zhou: Department of Urology and Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China
Yumin Jin: Department of Urology and Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China
Edoardo Lazzarini: Laboratory for Cardiovascular Theranostics, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale Lugano, Switzerland; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano Switzerland
Carolina Balbi: Cellular and Molecular Cardiology, Istituto Cardiocentro Ticino, Laboratories for Translational Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland; Center for Molecular Cardiology, Zurich, Switzerland
Oriol Juanola: Gastroenterology and Hepatology, Laboratories for Translational Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
Aurora Valdata: Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland (IOSI), CH6500 Bellinzona, Switzerland; Università della Svizzera Italiana, CH6900 Lugano, Switzerland; Department of Health Sciences and Technology (D-HEST) ETH Zurich, Zurich, CH, Switzerland
Silvia Bressan: Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland (IOSI), CH6500 Bellinzona, Switzerland; Università della Svizzera Italiana, CH6900 Lugano, Switzerland
Yu Zhan: Department of Environmental Science and Engineering, Sichuan University, Chengdu, Sichuan 610065, China
Fang Qi: Department of Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, People's Republic of China
Qiang Wei: Department of Urology and Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China
Lu Yang: Department of Urology and Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China; Corresponding authors.
Xiaoli Zou: Department of Sanitary Technology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China; Corresponding authors.
Shi Qiu: Department of Urology and Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China; Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland (IOSI), CH6500 Bellinzona, Switzerland; Corresponding authors.

Journal volume & issue: Vol. 184
p. 108447

Abstract

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Introduction: Although previous studies investigated the potential adverse effects of endocrine-disrupting chemicals (EDCs) on biological age acceleration and aging-related diseases, the mixed effect of multiple types of EDCs on biological age acceleration, including its potential underlying mechanism, remains unclear. Methods: Data from the National Health and Nutrition Examination Survey (NHANES) were used to analyze biological age measures, including Klemera-Doubal method biological age (KDM-BA), phenotypic age, and homeostatic dysregulation (HD). Weight quantile sum (WQS) regression was performed to screen biological age-related EDCs (BA-EDCs) and assess the mixed effect of BA-EDCs on biological age acceleration and aging-related disease. Targets of BA-EDCs were obtained from three databases, while heart aging-related genes were obtained from the Aging Anno database. Protein–protein interaction (PPI) network and MCODE algorithm were applied to identify potential interactions between BA-EDC targets and heart aging-related genes. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis were performed to identify related pathways. Results: This cross-sectional study included 1,439 participants. A decile increase in BA-EDCs co-exposure was associated with 0.31 years and 0.17 years of KDM-BA and phenotypic age acceleration, respectively. The mixed effect of BA-EDCs was associated with an increased prevalence of atherosclerotic cardiovascular disease (ASCVD). Vitamins C and E demonstrated a significant interaction effect on the association between BA-EDCs and KDM-BA acceleration. PPI network and functional enrichment analysis indicated that the AGE-RAGE signaling pathway in diabetic complications was significantly enriched. Conclusion: Our results showed that the co-exposure effect of BA-EDCs was associated with biological age acceleration and ASCVD, with the AGE-RAGE signaling pathway being the underlying mechanism. Vitamins C and E may also be an actionable target for preventing EDC-induced biological aging.

Published in Environment International

ISSN: 0160-4120 (Print)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Geography. Anthropology. Recreation: Environmental sciences
Website: https://www.journals.elsevier.com/environment-international

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