Nature Communications (Apr 2018)
TRPV1 SUMOylation regulates nociceptive signaling in models of inflammatory pain
- Yan Wang,
- Yingwei Gao,
- Quan Tian,
- Qi Deng,
- Yangbo Wang,
- Tian Zhou,
- Qiang Liu,
- Kaidi Mei,
- Yingping Wang,
- Huiqing Liu,
- Ruining Ma,
- Yuqiang Ding,
- Weifang Rong,
- Jinke Cheng,
- Jing Yao,
- Tian-Le Xu,
- Michael X. Zhu,
- Yong Li
Affiliations
- Yan Wang
- Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine
- Yingwei Gao
- Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine
- Quan Tian
- Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University
- Qi Deng
- Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine
- Yangbo Wang
- Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine
- Tian Zhou
- Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine
- Qiang Liu
- Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University
- Kaidi Mei
- Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University
- Yingping Wang
- Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine
- Huiqing Liu
- Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine
- Ruining Ma
- Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine
- Yuqiang Ding
- Department of Anatomy and Neurobiology, Collaborative Innovation Center for Brain Science, Tongji University School of Medicine
- Weifang Rong
- Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine
- Jinke Cheng
- Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine
- Jing Yao
- Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University
- Tian-Le Xu
- Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine
- Michael X. Zhu
- Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston
- Yong Li
- Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-018-03974-7
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 17
Abstract
SUMOylation is a post translational modification. Here the authors show that TRPV1, which conveys thermal nociception, is SUMOylated in DRGs in inflammatory conditions and contributes to pain behavior in mice.
