Nature Communications (Jun 2022)
Inherited basis of visceral, abdominal subcutaneous and gluteofemoral fat depots
- Saaket Agrawal,
- Minxian Wang,
- Marcus D. R. Klarqvist,
- Kirk Smith,
- Joseph Shin,
- Hesam Dashti,
- Nathaniel Diamant,
- Seung Hoan Choi,
- Sean J. Jurgens,
- Patrick T. Ellinor,
- Anthony Philippakis,
- Melina Claussnitzer,
- Kenney Ng,
- Miriam S. Udler,
- Puneet Batra,
- Amit V. Khera
Affiliations
- Saaket Agrawal
- Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
- Minxian Wang
- Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
- Marcus D. R. Klarqvist
- Data Sciences Platform, Broad Institute of MIT and Harvard
- Kirk Smith
- Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
- Joseph Shin
- Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
- Hesam Dashti
- Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
- Nathaniel Diamant
- Data Sciences Platform, Broad Institute of MIT and Harvard
- Seung Hoan Choi
- Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
- Sean J. Jurgens
- Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
- Patrick T. Ellinor
- Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
- Anthony Philippakis
- Data Sciences Platform, Broad Institute of MIT and Harvard
- Melina Claussnitzer
- Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
- Kenney Ng
- Center for Computational Health, IBM Research
- Miriam S. Udler
- Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
- Puneet Batra
- Data Sciences Platform, Broad Institute of MIT and Harvard
- Amit V. Khera
- Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
- DOI
- https://doi.org/10.1038/s41467-022-30931-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
The inherited basis of body fat distribution is not fully understood. Here, the authors use genetic data and MRI-derived measures of local adiposity to highlight fat depot-specific genetic architecture with implications for cardiometabolic health.
