Chimeric natural products derived from medermycin and the nature-inspired construction of their polycyclic skeletons

Shupeng Yin; Zhi Liu; Jingjing Shen; Yuwei Xia; Weihong Wang; Pengyan Gui; Qian Jia; Konthorn Kachanuban; Weiming Zhu; Peng Fu

doi:10.1038/s41467-022-32901-0

Nature Communications (Sep 2022)

Chimeric natural products derived from medermycin and the nature-inspired construction of their polycyclic skeletons

Shupeng Yin,
Zhi Liu,
Jingjing Shen,
Yuwei Xia,
Weihong Wang,
Pengyan Gui,
Qian Jia,
Konthorn Kachanuban,
Weiming Zhu,
Peng Fu

Affiliations

Shupeng Yin: Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China
Zhi Liu: Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China
Jingjing Shen: Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China
Yuwei Xia: Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China
Weihong Wang: Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China
Pengyan Gui: Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China
Qian Jia: Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China
Konthorn Kachanuban: Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China
Weiming Zhu: Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China
Peng Fu: Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China

DOI: https://doi.org/10.1038/s41467-022-32901-0
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 9

Abstract

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Nonenzymatic reactions play an important part in the formation of some natural products possessing complex skeletons. Here, the authors report the discovery of eight chimeric medermycin-type natural products and their nonenzymatic construction.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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