Effects of methotrexate upon inflammatory parameters induced by carrageenan in the mouse model of pleurisy

Eduardo Monguilhott Dalmarco; Tânia Silvia Fröde; Yara Santos Medeiros

doi:10.1080/09629350210000015700

Mediators of Inflammation (Jan 2002)

Effects of methotrexate upon inflammatory parameters induced by carrageenan in the mouse model of pleurisy

Eduardo Monguilhott Dalmarco,
Tânia Silvia Fröde,
Yara Santos Medeiros

Affiliations

Eduardo Monguilhott Dalmarco: Department of Clinical Analysis, Center of Health Sciences, Universidade Federal de Santa Catarina, Campus Universitário – Trindade, Florianópolis 88040–970, SC, Brazil
Tânia Silvia Fröde: Department of Clinical Analysis, Center of Health Sciences, Universidade Federal de Santa Catarina, Campus Universitário – Trindade, Florianópolis 88040–970, SC, Brazil
Yara Santos Medeiros: Department of Pharmacology, Center of Biological Sciences, Universidade Federal de Santa Catarina, Campus Universitário – Trindade, Florianópolis 88040–970, SC, Brazil

DOI: https://doi.org/10.1080/09629350210000015700
Journal volume & issue: Vol. 11, no. 5
pp. 299 – 306

Abstract

Read online

Background: The model of pleurisy induced by carrageenan exhibits a biphasic response (4 and 48 h) and permits the quantification of exudate, cell migration and certain enzymes such as myeloperoxidase (MPO) and adenosine-deaminase (ADA) that are markers of activated leukocytes.

Published in Mediators of Inflammation

ISSN: 0962-9351 (Print); 1466-1861 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Pathology
Website: https://onlinelibrary.wiley.com/journal/4792

About the journal