Recent advances in transition metal-free synthesis of furo[3,2-c]coumarin scaffolds: A comprehensive review

Abstract

Furocoumarins, a distinct class of coumarins, hold diverse therapeutic potential such as anti-inflammatory, anticancer, antiviral, antidepressant, and more. Focusing on the past seven years, the review highlights the transition metal-free synthesis of furo[3,2-c]coumarin scaffolds. Metal-free responses have gained popularity because of the growing awareness of the need to preserve natural resources and lessen the negative effects of metal usage on the environment. By categorizing techniques into two-component reactions and MCRs, the review provides a structured understanding of these synthetic methodologies.

Keywords

• Transition metal-free synthesis of Furo[3,2-c]coumarin
• Environmentally friendly one-pot synthesis
• Two-component reactions
• Multi-component reactions
• Green synthesis