Nature Communications (Mar 2016)
Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases
Abstract
High aldosterone levels cause heart damage independently of its well-known effect on blood pressure. Here, Cannavo et al. show that aldosterone-mediated cardiac pathology involves G protein-coupled receptor (GPCR) kinase 2 (GRK2) and GRK5 that integrate signals from angiotensin II receptor (AT1R).