Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases

Alessandro Cannavo; Daniela Liccardo; Akito Eguchi; Katherine J. Elliott; Christopher J. Traynham; Jessica Ibetti; Satoru Eguchi; Dario Leosco; Nicola Ferrara; Giuseppe Rengo; Walter J. Koch

doi:10.1038/ncomms10877

Nature Communications (Mar 2016)

Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases

Alessandro Cannavo,
Daniela Liccardo,
Akito Eguchi,
Katherine J. Elliott,
Christopher J. Traynham,
Jessica Ibetti,
Satoru Eguchi,
Dario Leosco,
Nicola Ferrara,
Giuseppe Rengo,
Walter J. Koch

Affiliations

Alessandro Cannavo: Department of Pharmacology and Center for Translational Medicine, Temple University School of Medicine
Daniela Liccardo: Department of Pharmacology and Center for Translational Medicine, Temple University School of Medicine
Akito Eguchi: Department of Pharmacology and Center for Translational Medicine, Temple University School of Medicine
Katherine J. Elliott: Department of Physiology and Cardiovascular Research Center, Temple University School of Medicine
Christopher J. Traynham: Department of Pharmacology and Center for Translational Medicine, Temple University School of Medicine
Jessica Ibetti: Department of Pharmacology and Center for Translational Medicine, Temple University School of Medicine
Satoru Eguchi: Department of Physiology and Cardiovascular Research Center, Temple University School of Medicine
Dario Leosco: Department of Translational Medical Science, University of Naples Federico II
Nicola Ferrara: Department of Translational Medical Science, University of Naples Federico II
Giuseppe Rengo: Department of Translational Medical Science, University of Naples Federico II
Walter J. Koch: Department of Pharmacology and Center for Translational Medicine, Temple University School of Medicine

DOI: https://doi.org/10.1038/ncomms10877
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 15

Abstract

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High aldosterone levels cause heart damage independently of its well-known effect on blood pressure. Here, Cannavo et al. show that aldosterone-mediated cardiac pathology involves G protein-coupled receptor (GPCR) kinase 2 (GRK2) and GRK5 that integrate signals from angiotensin II receptor (AT1R).

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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