Features of acute megakaryoblastic leukemia diagnosis in a child with Down syndrome

Abstract

We present a description of the difficulties in diagnosing acute megakaryoblastic leukemia in a child with Down syndrome aggravated by multiple comorbidities. In this case, a comprehensive assessment of clinical data, the results of an automatic complete blood count with a detailed interpretation of the entire range of parameters, as well as morphological and immunophenotypic bone marrow examination using an extended panel of monoclonal antibodies played a key role in the diagnosis.

Keywords

• down syndrome
• acute myeloid leukemia
• acute megakaryoblastic leukemia
• morphological examination of the bone marrow
• flow cytometry